Sox2

[Signal Transduction and Targeted Therapy] The authors postulated the hypothesis that DDR1 and its ligand might ignite the interaction between uveal melanoma (UM) cells and their surrounding niche of liver thereby conferring strengthened survival, proliferation, stemness and eventually promoting metastatic colonization in liver.

[Cancer Research] Interleukin enhancer binding factor 2 (ILF2) facilitated nuclear mRNA export and inhibited hMTR4-mediated exosomal degradation to promote stabilization and expression of SOX2, NANOG, and SALL4, resulting in enhanced stemness and tumor-initiating capacity of esophageal cancer cells.

[Oncogene] Researchers identified a novel SOX2-BRD4 transcriptional complex driving the expression of GLI1, the final effector of the Hedgehog/GLI (HH/GLI) pathway, providing a novel mechanism of non-canonical Smoothened-independent activation of HH/GLI signaling in melanoma.

[Cell Death & Disease] Scientists identified a novel lncRNA 408 (lnc408) in epithelial–mesenchymal transition-related breast CSCs (BCSCs). The lnc408 is high expressed in BCSCs in vitro and in vivo.

[Stem Cell Research] Researchers established the original footprint-free Vietnamese human induced pluripotent stem cell line, VRISGi001-A, from cord-blood derived CD34+ hematopoietic stem cells of a 35 year old healthy woman under cGMP-compliant process.

[Cancer Cell International] Colorectal cancer spheroids were developed using hanging drop and forced floating in serum-free and non-attachment conditions and their morphological features were evaluated by scanning electron microscopy.