Sox2

[Stem Cells] Researchers investigated how murine ESCs sense fluid shear stress and modulate a non‐canonical Wnt signaling response to promote pluripotency.

[Scientific Reports] The authors found that nectin-4 and p95-ErbB2, but not nectin-4 and either ErbB2 or ErbB2∆Ex16, cooperatively enhanced SOX2 gene expression and cell proliferation in a suspension culture.

[Cell Death & Disease] Scientists proposed a novel mechanism for transcription factor EB (TFEB) governing pluripotency of mESCs by regulating the pluripotency transcriptional network.

[Epigenomics] The authors reviewed the molecular basis of reprogramming, including the reprogramming factors, applied vectors and epigenetic modifications to provide a comprehensive guide for reprogramming studies.

[Life Sciences] The authors demonstrated that the miRNA miR-142-3p directly targeted the 3′ untranslated region of HMGA2, which encoded an onco-embryonic protein that was overexpressed in most cancers, including breast cancer.

[Nature Biomedical Engineering] Researchers showed that a double-network hydrogel could rapidly reprogram differentiated cancer cells into cancer stem cells.