Sox2

[Cell Death & Differentiation] The authors identified mitogen-activated protein kinase kinase 6 as a chromatin relaxer and found that it could significantly enhance reprogramming.

[Experimental and Molecular Medicine] Investigators showed that O-GlcNAcylation of Sox2 at threonine 258 regulated mouse ESC self-renewal and early cell fate.

[Biochemical Society Transactions] Scientists review the state-of-the-art knowledge of compartmentalization in the cell nucleus and the relevance of this process for transcriptional regulation, particularly in PSCs.

[Oncogene] The mechanism by which autophagy affects the self-renewal of CSCs remains unclear. Researchers investigated whether autophagy activation contributes to CSC properties of head and neck squamous cell carcinoma.

[Journal of Translational Medicine] Scientists explored the function of circular RNA nucleolar and coiled-body phosphoprotein 1 (circNOLC1) in cancer stem cells of breast cancer and the inhibitory impact of propofol on circNOLC1.

[American Journal of Hematology] The authors developed a murine model to investigate the in vivo properties of human iPSC-red blood cells (RBCs). iPSC lines were produced from human peripheral blood mononuclear cells by transient expression of plasmids containing OCT4, SOX2, MYC, KLF4 and BCL-XL genes.