T cells

[International Journal of Cancer] Investigators introduced a CD33-directed third-generation CAR T cell product for the treatment of patients with acute myeloid leukemia.

[Haematologica] The authors retrospectively reviewed the characteristics and outcomes of adult patients with relapsed/refractory large B-cell lymphoma treated with Standard of care axicabtagene ciloleucel or tisagenlecleucel .

[Clinical Cancer Research] Investigators identified EP4 as a specific target for prostate cancer immunotherapy and demonstrated that YY001 inhibited the growth of prostate tumors by regulating the immune microenvironment and strongly synergized with anti-programmed cell death protein-1 antibodies.

[Science Advances] Scientists compared the immune signature from hospitalized SARS-CoV-2–infected patients to patients hospitalized prepandemic with influenza or respiratory syncytial virus.

[Frontiers in Cell and Developmental Biology] The authors used a tripartite model of human hepatocellular carcinoma cell line and mesenchymal stromal cells co-cultured with peripheral blood mononuclear cells to investigate the impact of tumor and stromal cell interactions to the development of immunosuppressive tumor microenvironment.

[Cell Chemical Biology] To enable tumor-localized immunotherapy following intravenous administration, investigators chemically conjugated a polyspecific integrin-binding peptide (PIP) to an immunostimulant to generate a tumor-targeted immunomodulatory agent, referred to as PIP-CpG.