Hepatocellular Carcinoma Cells Are Protected From Immunolysis by Mesenchymal Stromal Cells Through Indoleamine 2,3 Dioxygenase

The authors used a tripartite model of human hepatocellular carcinoma cell line and mesenchymal stromal cells co-cultured with peripheral blood mononuclear cells to investigate the impact of tumor and stromal cell interactions to the development of immunosuppressive tumor microenvironment.