Adoptive Transfer of JC Virus-Specific T Lymphocytes for the Treatment of Progressive Multifocal Leukoencephalopathy

Scientists analyzed the safety and evaluate preliminary efficacy of polyomavirus JC-specific T cell therapy in a cohort of hematological patients with Progressive Multifocal Leukoencephalopathy.
[Annals of Neurology]
Berzero, G., Basso, S., Stoppini, L., Palermo, A., Pichiecchio, A., Paoletti, M., Lucev, F., Gerevini, S., Rossi, A., Vegezzi, E., Diamanti, L., Bini, P., Gastaldi, M., Delbue, S., Perotti, C., Seminari, E., Faraci, M., Luppi, M., Baldanti, F., … Comoli, P. (n.d.). Adoptive transfer of JC virus-specific T lymphocytes for the treatment of Progressive Multifocal Leukoencephalopathy. Annals of Neurology, n/a(n/a). https://doi.org/https://doi.org/10.1002/ana.26020 Cite
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CD14+ Monocytes Repress Gamma Globin Expression at Early Stages of Erythropoiesis

Researchers showed cultured erythroblasts were a mix of HbA restrictive and HbA/HbF expressing cells and that the proportion of cells in the latter population depends on the starting material.
[Scientific Reports]
Heshusius, S., Heideveld, E., von Lindern, M., & van den Akker, E. (2021). CD14+ monocytes repress gamma globin expression at early stages of erythropoiesis. Scientific Reports, 11(1), 1507. https://doi.org/10.1038/s41598-021-81060-7 Cite
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A Subset of Liver Resident Natural Killer Cells Is Expanded in Hepatitis C-Infected Patients with Better Liver Function

LMCs were less responsive to toll-like receptor stimulation than blood mononuclear cells, with fewer pro-inflammatory gene-expression pathways up-regulated after in vitro exposure to lipopolysaccharide and a TLR-7/8 agonist.
[Scientific Reports]
Doyle, E. H., Aloman, C., El-Shamy, A., Eng, F., Rahman, A., Klepper, A. L., Haydel, B., Florman, S. S., Fiel, M. I., Schiano, T., & Branch, A. D. (2021). A subset of liver resident natural killer cells is expanded in hepatitis C-infected patients with better liver function. Scientific Reports, 11(1), 1551. https://doi.org/10.1038/s41598-020-80819-8 Cite
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A Therapeutic Neutralizing Antibody Targeting Receptor Binding Domain of SARS-CoV-2 Spike Protein

Researchers screened human monoclonal antibodies targeting the receptor binding domain of the viral spike protein via antibody library constructed from peripheral blood mononuclear cells of a convalescent patient.
[Nature Communications]
Kim, C., Ryu, D.-K., Lee, J., Kim, Y.-I., Seo, J.-M., Kim, Y.-G., Jeong, J.-H., Kim, M., Kim, J.-I., Kim, P., Bae, J. S., Shim, E. Y., Lee, M. S., Kim, M. S., Noh, H., Park, G.-S., Park, J. S., Son, D., An, Y., … Lee, S.-Y. (2021). A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein. Nature Communications, 12(1), 288. https://doi.org/10.1038/s41467-020-20602-5 Cite
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The HIV Protease Inhibitor Saquinavir Attenuates Sepsis-Induced Acute Lung Injury and Promotes M2 Macrophage Polarization via Targeting Matrix Metalloproteinase-9

Scientists focused on the important role of macrophage polarization in cecal ligation puncture-mediated acute lung injury and determined the ability of saquinavir to maintain M2 over M1 phenotype partially through the inhibition of matrix metalloproteinase-9.
[Cell Death & Disease]
Tong, Y., Yu, Z., Chen, Z., Zhang, R., Ding, X., Yang, X., Niu, X., Li, M., Zhang, L., Billiar, T. R., Pitt, B. R., & Li, Q. (2021). The HIV protease inhibitor Saquinavir attenuates sepsis-induced acute lung injury and promotes M2 macrophage polarization via targeting matrix metalloproteinase-9. Cell Death & Disease, 12(1), 1–14. https://doi.org/10.1038/s41419-020-03320-0 Cite
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Single-Cell Transcriptomics Reveal Immune Mechanisms of the Onset and Progression of IgA Nephropathy

The authors performed single-cell RNA sequencing on kidneys and CD14+ peripheral blood mononuclear cells collected from IgA nephropathy (IgAN) and normal samples. In IgAN, upregulation of JCHAIN in mesangial cells provided insight into the trigger mechanism for the dimerization and deposition of IgA1 in situ.
[Cell Reports]
Single-Cell Transcriptomics Reveal Immune Mechanisms of the Onset and Progression of IgA Nephropathy: Cell Reports. (n.d.). Retrieved January 5, 2021, from https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31514-X Cite
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Molecular Subtype-Specific Responses of Colon Cancer Cells to the SMAC Mimetic Birinapant

Responses to the inhibitor of apoptosis protein antagonist Birinapant and oxaliplatin/5-fluorouracil were investigated in 14 colon cancer cell lines, representing the consensus molecular subtypes.
[Cell Death & Disease]
Fichtner, M., Bozkurt, E., Salvucci, M., McCann, C., McAllister, K. A., Halang, L., Düssmann, H., Kinsella, S., Crawford, N., Sessler, T., Longley, D. B., & Prehn, J. H. M. (2020). Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant. Cell Death & Disease, 11(11), 1–16. https://doi.org/10.1038/s41419-020-03232-z Cite
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Evidence for Liver and Peripheral Immune Cells Secreting Tumor-Suppressive Extracellular Vesicles in Melanoma Patients

The authors mimicked the interaction of tumor cells with liver cells and PBMC in vitro, and compared newly secreted extracellular vesicle (EV)-associated miRNAs and protein factors with those detected in melanoma patient`s plasma EV.
[Ebiomedicine]
Lee, J.-H., Eberhardt, M., Blume, K., Vera, J., & Baur, A. S. (2020). Evidence for liver and peripheral immune cells secreting tumor-suppressive extracellular vesicles in melanoma patients. EBioMedicine, 62. https://doi.org/10.1016/j.ebiom.2020.103119 Cite
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Quantitative Proteomics Reveal Lineage-Specific Protein Profiles in iPSC-Derived Marfan Syndrome Smooth Muscle Cells

The authors defined the aortic embryologic origin-specific proteome in a validated induced pluripotent stem cell smooth muscle cell model to identify novel protein markers associated with Marfan syndrome aneurysm phenotype.
[Scientific Reports]
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Macrophage Expression and Prognostic Significance of the Long Pentraxin PTX3 in COVID-19

RNA-sequencing analysis of peripheral blood mononuclear cells, single-cell bioinformatics analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and endothelial cells expressed high levels of PTX3 in patients with COVID-19.
[Nature Immunology]
Brunetta, E., Folci, M., Bottazzi, B., De Santis, M., Gritti, G., Protti, A., Mapelli, S. N., Bonovas, S., Piovani, D., Leone, R., My, I., Zanon, V., Spata, G., Bacci, M., Supino, D., Carnevale, S., Sironi, M., Davoudian, S., Peano, C., … Mantovani, A. (2020). Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19. Nature Immunology, 1–6. https://doi.org/10.1038/s41590-020-00832-x Cite
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LncRNA and mRNA Expression Profile of Peripheral Blood Mononuclear Cells in Primary Sjögren’s Syndrome Patients

Researchers elucidated the expression profile and the potential role of long non-coding RNA in the peripheral blood mononuclear cells of primary Sjögren’s syndrome patients.
[Scientific Reports]
Peng, Y., Luo, X., Chen, Y., Peng, L., Deng, C., Fei, Y., Zhang, W., & Zhao, Y. (2020). LncRNA and mRNA expression profile of peripheral blood mononuclear cells in primary Sjögren’s syndrome patients. Scientific Reports, 10(1), 19629. https://doi.org/10.1038/s41598-020-76701-2 Cite
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