Oestrogen Deprivation Induces Chemokine Production and Immune Cell Recruitment in In Vitro and In Vivo Models of Oestrogen Receptor-Positive Breast Cancer

Scientists investigated the effect of oestrogen deprivation on the expression of chemokines and immune infiltration in vitro and in an ER+ immunocompetent mouse model.
[Breast Cancer Research]
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Endometrial Mesenchymal Stem/Stromal Cells: The Enigma to Code Messages for Generation of Functionally Active Regulatory T Cells

The effect of MSCs on proliferation of anti-CD3/CD28-stimulated T CD4+ cells and generation of Tregs with or without pre-treatment with mitomycin C, IFN-γ and IL-1β was evaluated by flow cytometry.
[Stem Cell Research & Therapy]
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Intrauterine Administration of Peripheral Blood Mononuclear Cells (PBMCs) Improves Embryo Implantation in Mice by Regulating Local Treg/Th17 Cell Balance

Investigators determined the effect of intrauterine administration of mouse PBMCs prior to embryo implantation on endometrial receptivity and embryo implantation, and examined the underlying mechanism of Treg/Th17 cell balance following intrauterine administration of PBMCs.
[Journal of Reproduction and Development]
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PRAK-03202: A Triple Antigen Virus-Like Particle Vaccine Candidate against SARS CoV-2

The authors developed PRAK-03202, the world’s first triple antigen virus-like particle vaccine candidate, by cloning and transforming SARS-CoV-2 gene segments into a highly characterized S. cerevisiae-based D-Crypt™ platform, which induced SARS CoV-2 specific neutralizing antibodies in BALB/c mice.
[Heliyon]
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Generation of SCN1B Knock Out Induced Pluripotent Stem Cell (iPSC) Line (Refractory Epilepsy Syndrome and Brugada Syndrome Related Cell Line)

Scientists generated iPSCs from a normal individual by electroporation of peripheral blood mononuclear cells, and further generated a SCN1B-knockout human iPSC line via CRISPR/Cas9 gene editing.
[Stem Cell Research]
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Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance

Scientists described an anti-HLA-A2 CAR generated by grafting the complementarity-determining regions of a human monoclonal anti-HLA-A2 antibody into the framework regions of the Herceptin 4D5 single-chain variable fragment and fusing it with a CD28-ζ signaling domain.
[Frontiers in Immunology]
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eIF5B Regulates the Expression of PD-L1 in Prostate Cancer Cells by Interacting with Wig1

The effects of interference with eIF5B expression on the growth, morphology, and immunity of the tumor, as well as PD-L1 expression in the tumor, were verified by tumor xenograft assays in vivo.
[BMC Cancer]
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Toll-Like Receptor 1 as a Possible Target in Non-Alcoholic Fatty Liver Disease

The authors determined toll-like receptor (TLR) expression patterns in peripheral blood mononuclear cells of non-alcoholic fatty liver disease (NAFLD) patients and controls, their relation to intestinal microbiota and the impact of TLRs found altered in NAFLD development.
[Scientific Reports]
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Mitogen-Activated Protein Kinase Signaling in Childhood Asthma Development and Environment-Mediated Protection

Scientists aimed to investigate the role of MAPK signaling in childhood asthma and its environment-mediated protection, including a representative selection of 232 out of 1062 children from two cross-sectional cohorts and one birth cohort study.
[Pediatric Allergy and Immunology]
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Feline Adipose-Derived Mesenchymal Stem Cells Induce Effector Phenotype and Enhance Cytolytic Function of CD8+ T Cells

Modified mixed leukocyte reaction was performed between feline adipose-derived MSCs and PBMCs. Changes of cell cycle stages, phenotype and cellular senescence were determined through flow cytometry and gene expression analysis.
[Stem Cell Research & Therapy]
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Immune Normalization Strategy against Suboptimal Health Status: Safe and Efficacious Therapy Using Mixed-Natural Killer Cells

Researchers established in vitro cultured mixed-natural killer cells (NKM) to achieve immune normalization. The in vitro cytotoxicity of NKM cells was tenfold higher than that of peripheral blood mononuclear cells
[Aging-Us]
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