Using single-cell RNA sequencing, researchers characterized the peripheral blood mononuclear cells from uninfected controls and COVID-19 patients and cells in paired broncho-alveolar lavage fluid.
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The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing | Cell Discovery. (n.d.). Retrieved October 20, 2020, from https://www.nature.com/articles/s41421-020-00225-2 Cite
Scientists identified the landscape of tumor-infiltrating immune cells in the context of long non-coding RNA, known regulators of gene expression. They examined the lncRNA profiles of lung adenocarcinoma tumors by interrogating RNA sequencing data from microdissected and non-microdissected samples.
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Assessment of long non-coding RNA expression reveals novel mediators of the lung tumour immune response | Scientific Reports. (n.d.). Retrieved October 16, 2020, from https://www.nature.com/articles/s41598-020-73787-6 Cite
Researchers investigated the viability and proliferation of osteoblasts, fibroblasts and oral keratinocytes under stratified medium modification and assessed the differentiation of osteoclasts in each co-culture.
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Establishment and validation of an in vitro co-culture model for oral cell lines using human PBMC-derived osteoclasts, osteoblasts, fibroblasts and keratinocytes | Scientific Reports. (n.d.). Retrieved October 8, 2020, from https://www.nature.com/articles/s41598-020-73941-0 Cite
The authors’ in vitro study indicated that high glucose increased monocyte/endothelial adhesion, endothelial adhesion molecule expression and p65 phosphorylation in human umbilical vein endothelial cells.
[Experimental and Molecular Medicine]
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The proliferation and viability of both cell types were not significantly influenced by magnesium (Mg). When human umbilical cord perivascular cells were cultured with degradable Mg, a moderate inflammation, and an increased pro-healing M2 macrophage phenotype were observed.
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The authors present a new protocol based on surface enhanced resonance Raman scattering (SERRS) gold multivalent nanostructures to identify and enumerate tumor cells with epithelial and mesenchymal markers.
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Litti, L., Colusso, A., Pinto, M., Ruli, E., Scarsi, A., Ventura, L., Toffoli, G., Colombatti, M., Fracasso, G., & Meneghetti, M. (2020). SERRS multiplexing with multivalent nanostructures for the identification and enumeration of epithelial and mesenchymal cells. Scientific Reports, 10(1), 15805. https://doi.org/10.1038/s41598-020-72911-w Cite
Scientists investigated the effects of HIV infection on immune cell exhaustion at the transcriptomic level by analyzing single-cell RNA sequencing of peripheral blood mononuclear cells from four healthy subjects and six HIV-infected donors.
[Emerging Microbes & Infections]
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The authors found that bronchoalveolar lavage fluid exosomes from sarcoidosis patients, but not from healthy individuals, induced a dose-dependent elevation of intracellular IL-1β in monocytes.
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SARS-CoV-2−specific CD8+ T cells recovered from convalescent COVID-19 patients had an atypically high prevalence of stem cell memory, central memory, and naïve phenotypes.
[Proceedings of the National Academy of Sciences of the United States of America]
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Habel, J. R., Nguyen, T. H. O., Sandt, C. E. van de, Juno, J. A., Chaurasia, P., Wragg, K., Koutsakos, M., Hensen, L., Jia, X., Chua, B., Zhang, W., Tan, H.-X., Flanagan, K. L., Doolan, D. L., Torresi, J., Chen, W., Wakim, L. M., Cheng, A. C., Doherty, P. C., … Kedzierska, K. (2020). Suboptimal SARS-CoV-2−specific CD8+ T cell response associated with the prominent HLA-A*02:01 phenotype. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2015486117 Cite
Using a humanized lupus mouse model, researchsrs showed that the transfer of Th17 cell-depleted PBMCs from lupus patients resulted in a significantly reduced plasma cell response and attenuated renal damage in recipient mice compared to the transfer of total systemic lupus erythematosus PBMCs.
[Cellular & Molecular Immunology]
Researchers report the first observation of sterol regulatory element binding protein-2 (SREBP-2) C-terminal fragment in COVID-19 patients’ blood and proposed SREBP-2 C-terminal fragment as an indicator for determining severity.
[Signal Transduction and Targeted Therapy]
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Lee, W., Ahn, J. H., Park, H. H., Kim, H. N., Kim, H., Yoo, Y., Shin, H., Hong, K. S., Jang, J. G., Park, C. G., Choi, E. Y., Bae, J.-S., & Seo, Y.-K. (2020). COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm. Signal Transduction and Targeted Therapy, 5(1), 1–11. https://doi.org/10.1038/s41392-020-00292-7 Cite