Adenosine Deaminase Modulates Metabolic Remodeling and Orchestrates Joint Destruction in Rheumatoid Arthritis

Scientists presented an integrative analysis of clinical data, cytokines, serum metabolomics in rheumatoid arthritis patients and mechanistic studies on denosine deaminase-mediated effects on in vitro cell culture models.
[Scientific Reports]
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Immunologic Mechanisms of Seasonal Influenza Vaccination Administered by Microneedle Patch from a Randomized Phase I Trial

Investigators compared the humoral and cellular immunologic responses in a subset of participants receiving influenza vaccination by microneedle patches to the intramuscular route of administration.
[NPJ Vaccines]
Rouphael, N. G., Lai, L., Tandon, S., McCullough, M. P., Kong, Y., Kabbani, S., Natrajan, M. S., Xu, Y., Zhu, Y., Wang, D., O’Shea, J., Sherman, A., Yu, T., Henry, S., McAllister, D., Stadlbauer, D., Khurana, S., Golding, H., Krammer, F., … Prausnitz, M. R. (2021). Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial. Npj Vaccines, 6(1), 1–9. https://doi.org/10.1038/s41541-021-00353-0 Cite
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The Immunoregulatory Function of Peripheral Blood CD71+ Erythroid Cells in Systemic-Onset Juvenile Idiopathic Arthritis

The authors studied the gene expression and function in systemic-onset juvenile idiopathic arthritis to assess the biological role of CD71+ erythroid cells in systemic inflammation.
[Scientific Reports]
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HLA-DR Cancer Cells Expression Correlates with T Cell Infiltration and Is Enriched in Lung Adenocarcinoma with Indolent Behavior

Scientists identified cellular subpopulations of epithelial cancer cells and their microenvironment and validated their results by multiplex immunofluorescence applied to a tissue microarray of long and short-predicted survival lung adenocarcinoma.
[Scientific Reports]
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Itacitinib Prevents Xenogeneic GVHD in Humanized Mice

Mice were followed for xenogeneic graft-versus-host disease score and survival. Human T-cell engraftment and as well as human T-cell subtypes were monitored in blood on days 14, 21, and 28 after transplantation.
[Bone Marrow Transplantation]
Courtois, J., Ritacco, C., Dubois, S., Canti, L., Vandenhove, B., Seidel, L., Daulne, C., Caers, J., Servais, S., Beguin, Y., Ehx, G., & Baron, F. (2021). Itacitinib prevents xenogeneic GVHD in humanized mice. Bone Marrow Transplantation, 1–10. https://doi.org/10.1038/s41409-021-01363-1 Cite
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Understanding LRRK2 Kinase Activity in Preclinical Models and Human Subjects through Quantitative Analysis of LRRK2 and pT73 Rab10

Researchers developed and applied such assays to measure the levels of leucine-rich repeat kinase 2 as well as the phosphorylation of LRRK2 itself or one of its substrates, Rab10.
[Scientific Reports]
Wang, X., Negrou, E., Maloney, M. T., Bondar, V. V., Andrews, S. V., Montalban, M., Llapashtica, C., Maciuca, R., Nguyen, H., Solanoy, H., Arguello, A., Przybyla, L., Moerke, N. J., Huntwork-Rodriguez, S., & Henry, A. G. (2021). Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10. Scientific Reports, 11(1), 12900. https://doi.org/10.1038/s41598-021-91943-4 Cite
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CD86+ Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-Cell Responses

Researchers used multicolor flow cytometry and immunohistochemistry to elucidate abundance and spatial distribution of these antigen-presenting B cells in blood and tumor samples of 238 cancer patients.
[Cancer Immunology Research]
CD86+ antigen-presenting B cells are increased in cancer, localize in tertiary lymphoid structures, and induce specific T-cell responses | Cancer Immunology Research. (n.d.). Retrieved June 22, 2021, from https://cancerimmunolres.aacrjournals.org/content/early/2021/06/21/2326-6066.CIR-20-0949 Cite
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Bioheng Biotech Received Orphan Drug Designation from the US FDA for the Treatment of T-ALL

Nanjing Bioheng Biotech Co., Ltd. announced UCAR T cell therapy product targeting CD7, received Orphan Drug Designation from the US FDA for the treatment of T-cell acute lymphoblastic leukemia (T-ALL).
[Bioheng Biotech Co., Ltd.]
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Immune Modulation via Adipose Derived Mesenchymal Stem Cells Is Driven by Donor Sex In Vitro

The authors examined the potency and functionality of both female and male adipose derived mesenchymal stem cells in order to gain further insights into donor selection.
[Scientific Reports]
Mckinnirey, F., Herbert, B., Vesey, G., & McCracken, S. (2021). Immune modulation via adipose derived Mesenchymal Stem cells is driven by donor sex in vitro. Scientific Reports, 11(1), 12454. https://doi.org/10.1038/s41598-021-91870-4 Cite
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Therapeutic Effect of IL1β Priming Tonsil Derived-Mesenchymal Stem Cells in Osteoporosis

IL1β priming Tonsil-derived MSCs had an enhanced osteogenic differentiation and secreted factors that regulate both osteoclastogenesis and osteoblastogenesis.
[Tissue Engineering and Regenerative Medicine]
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Phase I/II Clinical Trial of Adoptive Cell Transfer of Sorted Specific T Cells for Metastatic Melanoma Patients

Scientists reported results from a phase I/II clinical trial in which six metastatic HLA-A2 melanoma patients received autologous antigen-specific T-cells produced from peripheral blood mononuclear cells, after peptide stimulation in vitro, followed by sorting with HLA-peptide multimers and amplification.
[Cancer Immunology Immunotherapy]
Dréno, B., Khammari, A., Fortun, A., Vignard, V., Saiagh, S., Beauvais, T., Jouand, N., Bercegay, S., Simon, S., Lang, F., & Labarrière, N. (2021). Phase I/II clinical trial of adoptive cell transfer of sorted specific T cells for metastatic melanoma patients. Cancer Immunology, Immunotherapy. https://doi.org/10.1007/s00262-021-02961-0 Cite
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