Lung-Resident Memory B Cells Established after Pulmonary Influenza Infection Display Distinct Transcriptional and Phenotypic Profiles

Scientists characterized tissue-resident memory B cells that are stably maintained in the lungs of mice after pulmonary influenza infection.
[Science Immunology]
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Gene Therapy of Prostate Cancer Using Liposomes Containing Perforin Expression Vector Driven by the Promoter of Prostate-Specific Antigen Gene

The authors investigated the therapeutic potential of liposomes containing perforin expression vector driven by the promotor of prostate-specific antigen.
[Scientific Reports]
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NLRP3 Inflammasome Activation in Human Peripheral Blood Mononuclear Cells Induced by Venoms Secreted PLAM2s

Peripheral blood mononuclear cells were isolated by density gradient and incubated with RPMI, LPS, BthTX-I or BthTX-II isolated from Bothrops jararacussu venom, to evaluate viability, and the results showed that there was no cell death.
[International Journal of Biological Macromolecules]
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Reinvestigation of Classic T Cell Subsets and Identification of Novel Cell Subpopulations by Single-Cell RNA Sequencing

The authors integrated six bead-enriched T cell subsets with 62,235 single-cell transcriptomes from human PBMCs and clustered them into nine scRNA-seq clustered populations.
[Journal of Immunology]
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Key Interactions in the Trimolecular Complex Consisting of the Rheumatoid Arthritis-Associated DRB1*04:01 Molecule, the Major Glycosylated Collagen II Peptide and the T Cell Receptor

The crystal structures identified peptide binding to DRB1*04:01 and potential side chain exposure to T cells.
[Annals of the Rheumatic Diseases]
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Adenosine Receptor A2a Blockade by Caffeine Increases IFN–Gamma Production in Th1 Cells from Patients with Rheumatoid Arthritis

Peripheral blood mononuclear cells were obtained from the peripheral blood of healthy individuals and patients with rheumatoid arthritis.
[Scandinavian Journal of Rheumatology]
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Single-Cell Analysis Reveals the Immune Characteristics of Myeloid Cells and Memory T Cells in Recovered COVID-19 Patients with Different Severities

According to large-scale single-cell analysis, recovered patients, who had severe symptoms, still exhibited peripheral immune disorders one-two months after symptom onset.
[Frontiers in Immunology]
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TGFβ2 Induces the Soluble Isoform of CTLA-4 – Implications for CTLA-4 Based Checkpoint Inhibitor Antibodies in Malignant Melanoma

Scientists examined the effect of selectively blocking the function of sCTLA-4 on in vitro immune responses from volunteer healthy or melanoma patient PBMC samples.
[Frontiers in Immunology]
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Advances in NK Cell Production

Scientists summarize the recent advances in expansion strategies with or without genetic manipulation of NK cells derived from various cellular sources.
[Cellular & Molecular Immunology]
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Towards Large-Scale Identification of HLA-Restricted T Cell Epitopes from Four Vaccine Candidate Antigens in a Malaria Endemic Community in Ghana

Investigators identified immunodominant portions of four malaria vaccine candidate antigens using peripheral blood mononuclear cells from adults with life-long exposure to malaria parasites.
[Vaccine]
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Circulating CD137+ T Cells Correlate with Improved Response to Anti-PD1 Immunotherapy in Cancer Patients

Investigators examined the role of the CD137+ T cells in the improvement of patients’ selection for immunotherapy treatment.
[Clinical Cancer Research]
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