Anti-CLL1 Chimeric Antigen Receptor T Cell Therapy in Children with Relapsed/Refractory Acute Myeloid Leukemia

Scientists tested the safety and efficacy of chimeric antigen receptor T cell therapy in refractory/relapsed acute myeloid leukemia .
[Clinical Cancer Research]
Zhang, H., Wang, P., Li, Z., He, Y., Gan, W., & Jiang, H. (2021). Anti-CLL1 chimeric antigen receptor T cell therapy in children with relapsed/refractory acute myeloid leukemia. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-4543 Cite
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Myeloma-Secreted Galectin-1 Potently Interacts with CD304 on Monocytic Myeloid-Derived Suppressor Cells

Scientists investigated the interaction between CD304 expression on myeloid-derived suppressor cells and galectin-1 from malignant plasma cells in the context of autologous stem cell transplantation for multiple myeloma.
[Cancer Immunology Research]
Lim, J.-Y., Kim, T. W., Ryu, D.-B., Park, S.-S., Lee, S.-E., Kim, B.-S., & Min, C.-K. (2021). Myeloma-secreted galectin-1 potently interacts with CD304 on monocytic myeloid-derived suppressor cells. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.CIR-20-0663 Cite
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Quantification of T Cell Clonality in Human T Cell Leukaemia Virus Type-1 Carriers Can Detect the Development of Adult T Cell Leukaemia Early

Scientists showed that adult T cell leukemia/lymphoma (ATL) could be detected early in HTLV-1-carriers through quantification of T-cell receptor (TCR)Vβ subunit diversity on T-cells infected with HTLV-1 using an ‘oligoclonality index’.
[Blood Cancer Journal]
Wolf, S. N., Haddow, J., Greiller, C., Taylor, G. P., Cook, L. B. M., & Rowan, A. G. (2021). Quantification of T cell clonality in human T cell leukaemia virus type-1 carriers can detect the development of adult T cell leukaemia early. Blood Cancer Journal, 11(3), 1–11. https://doi.org/10.1038/s41408-021-00458-8 Cite
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Umbilical Cord Blood-Derived Microglia-Like Cells to Model COVID-19 Exposure

Scientists generated patient-derived microglial-like cell models unique to each neonate from reprogrammed umbilical cord blood mononuclear cells, adapting and extending a novel methodology previously validated for adult peripheral blood mononuclear cells.
[Translational Psychiatry]
Sheridan, S. D., Thanos, J. M., De Guzman, R. M., McCrea, L. T., Horng, J. E., Fu, T., Sellgren, C. M., Perlis, R. H., & Edlow, A. G. (2021). Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure. Translational Psychiatry, 11(1), 1–9. https://doi.org/10.1038/s41398-021-01287-w Cite
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Fasting-Induced FOXO4 Blunts Human CD4+ T Helper Cell Responsiveness

Investigators showed that fasting in humans was sufficient to blunt CD4+ T helper cell responsiveness.
[Nature Metabolism]
Han, K., Singh, K., Rodman, M. J., Hassanzadeh, S., Wu, K., Nguyen, A., Huffstutler, R. D., Seifuddin, F., Dagur, P. K., Saxena, A., McCoy, J. P., Chen, J., Biancotto, A., Stagliano, K. E. R., Teague, H. L., Mehta, N. N., Pirooznia, M., & Sack, M. N. (2021). Fasting-induced FOXO4 blunts human CD4 + T helper cell responsiveness. Nature Metabolism, 1–9. https://doi.org/10.1038/s42255-021-00356-0 Cite
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Characterization of a Natural Variant of Human NDP52 and Its Functional Consequences on Mitophagy

Researchers qualitatively and quantitatively studied the main players in PINK1-mediated mitophagy in peripheral blood mononuclear cells of patients with relapsing–remitting multiple sclerosis.
[Cell Death & Differentiation]
Di Rita, A., Angelini, D. F., Maiorino, T., Caputo, V., Cascella, R., Kumar, M., Tiberti, M., Lambrughi, M., Wesch, N., Löhr, F., Dötsch, V., Carinci, M., D’Acunzo, P., Chiurchiù, V., Papaleo, E., Rogov, V. V., Giardina, E., Battistini, L., & Strappazzon, F. (2021). Characterization of a natural variant of human NDP52 and its functional consequences on mitophagy. Cell Death & Differentiation, 1–18. https://doi.org/10.1038/s41418-021-00766-3 Cite
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Quality and Quantity Culture Effectively Restores Functional and Proliferative Capacities of Endothelial Progenitor Cell in End-Stage Renal Disease Patients

Peripheral blood mononuclear cells were isolated from age-matched control subjectsand end-stage renal disease patients, followed by culture in either conventional endothelial progenitor cell culture for one month or in quality and quantity culture for seven days, respectively.
[Stem Cell Research]
Huang, T.-H., Lee, M. S., Sung, P.-H., Chen, Y.-L., Chiang, J. Y., Yang, C.-C., Sheu, J.-J., & Yip, H.-K. (2021). Quality and quantity culture effectively restores functional and proliferative capacities of endothelial progenitor cell in end-stage renal disease patients. Stem Cell Research, 53, 102264. https://doi.org/10.1016/j.scr.2021.102264 Cite
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Ex Vivo Characterization of Breg Cells in Patients with Chronic Chagas Disease

Researchers studied the proportion of different B cell subsets and their capacity to secrete IL-10 ex vivo in peripheral blood from patients with or without chronic Chagas disease cardiomyopathy.
[Scientific Reports]
Girard, M. C., Acevedo, G. R., Ossowski, M. S., Fernández, M., Hernández, Y., Chadi, R., & Gómez, K. A. (2021). Ex vivo characterization of Breg cells in patients with chronic Chagas disease. Scientific Reports, 11(1), 5511. https://doi.org/10.1038/s41598-021-84765-x Cite
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Identification of Human Immune Cell Subtypes Most Responsive to IL-1β–Induced Inflammatory Signaling Using Mass Cytometry

Researchers identified effector memory CD4+ T cells and CD4−CD8low/−CD161+ T cells, specifically those positive for the chemokine receptor CCR6, as the circulating immune subtypes with the greatest response to IL-1β.
[Science Signaling]
Kothari, H., Williams, C. M., McSkimming, C., Drago, F., Marshall, M. A., Garmey, J., Vigneshwar, M., Zunder, E. R., & McNamara, C. A. (2021). Identification of human immune cell subtypes most responsive to IL-1β–induced inflammatory signaling using mass cytometry. Science Signaling, 14(673). https://doi.org/10.1126/scisignal.abc5763 Cite
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MTH1 Inhibitors for the Treatment of Psoriasis

Using the Imiquimod psoriasis mouse model, researchers found that MutT homolog 1 (MTH1) inhibition diminished psoriatic histological characteristics and normalized the levels of neutrophils and T cells in skin and skin-draining lymph nodes. The inhibition abolished the expression of Th17-associated cytokines in the skin, which was in line with decreased levels of IL-17-producing γδ T cells in lymph nodes.
[Journal of Investigative Dermatology]
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Mesenchymal Stem Cells Regulate Type 2 Innate Lymphoid Cells via Regulatory T Cells through ICOS‐ICOSL Interaction

The authors investigated the potential immunomodulatory effects of mesenchymal stem cells on group 2 innate lymphoid cells in peripheral blood mononuclear cells from allergic rhinitis patients and healthy subjects.
[Stem Cells]
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