Scientists presented an integrative analysis of clinical data, cytokines, serum metabolomics in rheumatoid arthritis patients and mechanistic studies on denosine deaminase-mediated effects on in vitro cell culture models.
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Investigators compared the humoral and cellular immunologic responses in a subset of participants receiving influenza vaccination by microneedle patches to the intramuscular route of administration.
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Rouphael, N. G., Lai, L., Tandon, S., McCullough, M. P., Kong, Y., Kabbani, S., Natrajan, M. S., Xu, Y., Zhu, Y., Wang, D., O’Shea, J., Sherman, A., Yu, T., Henry, S., McAllister, D., Stadlbauer, D., Khurana, S., Golding, H., Krammer, F., … Prausnitz, M. R. (2021). Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial. Npj Vaccines, 6(1), 1–9. https://doi.org/10.1038/s41541-021-00353-0 Cite
The authors studied the gene expression and function in systemic-onset juvenile idiopathic arthritis to assess the biological role of CD71+ erythroid cells in systemic inflammation.
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Scientists identified cellular subpopulations of epithelial cancer cells and their microenvironment and validated their results by multiplex immunofluorescence applied to a tissue microarray of long and short-predicted survival lung adenocarcinoma.
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Mice were followed for xenogeneic graft-versus-host disease score and survival. Human T-cell engraftment and as well as human T-cell subtypes were monitored in blood on days 14, 21, and 28 after transplantation.
[Bone Marrow Transplantation]
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Researchers developed and applied such assays to measure the levels of leucine-rich repeat kinase 2 as well as the phosphorylation of LRRK2 itself or one of its substrates, Rab10.
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Wang, X., Negrou, E., Maloney, M. T., Bondar, V. V., Andrews, S. V., Montalban, M., Llapashtica, C., Maciuca, R., Nguyen, H., Solanoy, H., Arguello, A., Przybyla, L., Moerke, N. J., Huntwork-Rodriguez, S., & Henry, A. G. (2021). Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10. Scientific Reports, 11(1), 12900. https://doi.org/10.1038/s41598-021-91943-4 Cite
Researchers used multicolor flow cytometry and immunohistochemistry to elucidate abundance and spatial distribution of these antigen-presenting B cells in blood and tumor samples of 238 cancer patients.
[Cancer Immunology Research]
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CD86+ antigen-presenting B cells are increased in cancer, localize in tertiary lymphoid structures, and induce specific T-cell responses | Cancer Immunology Research. (n.d.). Retrieved June 22, 2021, from https://cancerimmunolres.aacrjournals.org/content/early/2021/06/21/2326-6066.CIR-20-0949 Cite
Nanjing Bioheng Biotech Co., Ltd. announced UCAR T cell therapy product targeting CD7, received Orphan Drug Designation from the US FDA for the treatment of T-cell acute lymphoblastic leukemia (T-ALL).
[Bioheng Biotech Co., Ltd.]
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The authors examined the potency and functionality of both female and male adipose derived mesenchymal stem cells in order to gain further insights into donor selection.
IL1β priming Tonsil-derived MSCs had an enhanced osteogenic differentiation and secreted factors that regulate both osteoclastogenesis and osteoblastogenesis.
[Tissue Engineering and Regenerative Medicine]
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Scientists reported results from a phase I/II clinical trial in which six metastatic HLA-A2 melanoma patients received autologous antigen-specific T-cells produced from peripheral blood mononuclear cells, after peptide stimulation in vitro, followed by sorting with HLA-peptide multimers and amplification.
[Cancer Immunology Immunotherapy]
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Dréno, B., Khammari, A., Fortun, A., Vignard, V., Saiagh, S., Beauvais, T., Jouand, N., Bercegay, S., Simon, S., Lang, F., & Labarrière, N. (2021). Phase I/II clinical trial of adoptive cell transfer of sorted specific T cells for metastatic melanoma patients. Cancer Immunology, Immunotherapy. https://doi.org/10.1007/s00262-021-02961-0 Cite