T cells

[Oncogene] Researchers showed that the activation of the RON receptor tyrosine kinase signaling pathway specifically in macrophages supports breast cancer growth and metastasis.

[Immatics N.V.] Immatics N.V. announced an interim clinical data update from its TCR-engineered cell therapy approach ACTengine® IMA203 targeting PRAME.

[Cancer Research] Researchers revealed that delivery of miR-122 was associated with downregulation of key genes in involved in metastatic and cancer inflammation pathways, including several pro-inflammatory factors, matrix metalloproteinases, and other extracellular matrix degradation enzymes.

[Cancer Research] The authors demonstrated that inhibition of fibroblast growth factor receptor 3 (FGFR3) in FGFR3-activated bladder cancer elevated PD-L1 protein levels by affecting its ubiquitination, thereby inhibiting the anti-tumor activity of CD8+ T cells.

[Proceedings of the National Academy of Sciences of the United States of America] Invariant natural killer T (iNKT) cells from peripheral blood and colonic mucosa were investigated during treated and untreated acute HIV-1 infection.

[Cell Death & Disease] The authors detected a higher concentration of CD73+ tumor-derived extracellular vesicles enriched in exosomes in central and peripheral body fluids of glioblastoma patients than in those of patients with other brain tumors.