T cells

[Nature Immunology] The authors confirmed pervasive phenotypic, functional and transcriptional differences between memory and exhausted antigen-specific CD8+ T cells in human hepatitis C virus infection before and after treatment.

[Cell Reports] Type 1 diabetes (T1D) patients had a lower serum MOTS-c level than did healthy controls. Furthermore, MOTS-c reduced T cell activation by alleviating T cells from the glycolytic stress in T1D patients, suggesting therapeutic potential.

[eLife] Using primary human CD4+ T cells, researchers showed that when T cells form immunological synapse with stimulating antibody-coated surfaces, the lamellipodia are stiffer than the cell body.

[Scientific Reports] The authors used recently described RNA ligands for toll-like receptor (TLR)7 and TLR8 together with Vγ9Vδ2 T-cell specific pyrophosphate antigens to analyze the rapid cytokine induction in Vδ2 T cells as well as the accessory cell requirements.

[Journal of Investigative Dermatology] Increased autoantigen presentation by HLA molecules, cross-activation of pathogen-induced T cells against autologous structures, altered metabolism of self-proteins, and excessive production of proinflammatory signals may all contribute to the breakdown of immune tolerance and the development of autoimmune skin diseases.

[Bone Marrow Transplantation] Investigators evaluated the immune reconstitution of patients receiving omidubicel grafts during the first six months post-transplant, as IR is critical for favorable outcomes of the procedure.