T cells

[Abcuro, Inc.] Abcuro, Inc. and ImaginAb shared initial results of a study demonstrating the use of ImmunoPET technology to image T cell infiltration of skeletal muscle in patients with inclusion body myositis, an autoimmune disease in which cytotoxic CD8+ T cells chronically attack muscle cells, leading to progressive weakness and severe disability.

[Nature Communications] Researchers showed that systemic delivery of αCD40 induced hypofunctional T cells and impaired the response to immune checkpoint inhibitors in pre-clinical glioma models.

[Human Genomics] Scientists used the commercial Chromium platform to perform sc-ATAC-seq to measure chromatin accessibility in 11,611 single umbilical cord blood cells derived from one trisomy 18 syndrome patient and one healthy donor.

[Leukemia] Scientists review the relevance and complications of clonal hematopoiesis for the treatment of hematologic malignancies with cell therapeutic approaches.

[Molecular Therapy] IdeS cleavage of host IgG averted Fc-dependent phagocytosis and lysis, and the residual F(ab')2 fragments remained on the surface, providing cells with an inert shield from additional IgG deposition.

[Nature Communications] Researchers showed that in vitro treatment of cytotoxic T lymphocytes and CAR T cells with pentanoate and butyrate increases the function of mTOR as a central cellular metabolic sensor, and inhibits class I histone deacetylase activity.