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T cells

Chimeric Antigen Receptor (CAR) T-cell Treatment for Mantle Cell Lymphoma (MCL)

[Therapeutic Advances in Hematology] Investigators provided an overview for the available management strategies for relapsed mantle cell lymphoma (MCL) and examines the role of CAR T cell in the current and future treatment of MCL.

Modelling T Cell Immunity against Hepatitis C Virus with Liver Organoids in a Microfluidic Coculture System

[Open Biology] Researchers developed a CD8+ T cell and adult stem cell liver organoid system using a microfluidic chip to coculture 3D human liver organoids embedded in extracellular matrix with HLA-matched primary human T cells in suspension.

Post-Translational Modification of MALT1 and Its Role in B Cell- and T Cell-Related Diseases

[Biochemical Pharmacology] Investigators summarize recent progress in relevant studies regarding the physiological and pathophysiological functions of MALT1, post-translational modifications of MALT1 and its role in B cell- and T cell- related diseases.

Decidual Immune Response Following COVID-19 during Pregnancy Varies by Timing of Maternal SARS-CoV-2 Infection

[Journal of Reproductive Immunology] Investigators hypothesized that decidual leukocytes were altered by maternal SARS-CoV-2 infection in pregnancy and that this decidual immune response was shaped by the timing of infection during gestation.

Phosphorylation of Serine-893 in CARD11 Suppresses the Formation and Activity of the CARD11-BCL10-MALT1 Complex in T and B Cells

[Science Signaling] Researchers demonstrated that PKCθ/β-dependent CARD11 phosphorylation also suppressed CARD11 functions in T or B cells.

Liver Environment–Imposed Constraints Diversify Movement Strategies of Liver-Localized CD8 T Cells

[Journal of Immunology] Investigators developed a protocol to generate stable numbers of liver-located CD8 T cells, and used intravital microscopy to record movement patterns of CD8 T cells in livers of live mice.

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