T cells

[Science] Scientists developed a CRISPR activation and CRISPR interference discovery platform in primary human T cells and performed genome-wide screens for functional regulators of cytokine production in response to stimulation.

[Science] By mapping 55 neoantigen-specific TCR clonotypes from 10 metastatic human tumors to their single-cell transcriptomes, scientists identified signatures of CD8+ and CD4+ neoantigen-reactive tumor-infiltrating lymphocytes.

[Science Immunology] Scientists studied neutralizing antibodies and T-cell responses targeting SARS-CoV-2 D614G (wildtype), and Beta, Delta, and Omicron variants of concern in a cohort of 60 health care workers after immunization with ChAdOx-1 S, Ad26.COV2.S, mRNA-1273 or BNT162b2.

[Circulation] Investigators utilized mouse models of reperfused myocardial infarction, angiotensin II and phenylephrine infusion, and diphtheria toxin cardiomyocyte ablation to investigate C-C chemokine ligand 17.

[eLife] Scientists identified Zfp335 transcription factor as a new player in the regulatory network controlling thymocyte development in mice.

[Annual Reviews of Immunology] Scientists discussed known T cell–microbe interactions in the gut and placed them in the context of an algorithmic framework of recognition, context-dependent interpretation, and response circuits across multiple levels of microbial recognition resolution.