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T cells

CD97 Is Associated with Mitogenic Pathway Activation, Metabolic Reprogramming, and Immune Microenvironment Changes in Glioblastoma

[Scientific Reports] Using in silico and in vitro techniques, investigators demonstrated heterogeneous expression of CD97, a leukocyte adhesion marker, in human glioblastoma.

Sustainable Antiviral Efficacy of Rejuvenated HIV-Specific Cytotoxic T Lymphocytes Generated from Induced Pluripotent Stem Cells

[Journal of Virology] Scientists assessed the antiviral efficacy of HIV-specific iPSC-cytotoxic T lymphocytes by single- and multiple-round viral suppression assays.

In Vivo Imaging of Nanoparticle-Labeled CAR T Cells

[Proceedings of the National Academy of Sciences of the United States of America] Scientists developed a clinically translatable approach for labeling CAR T cells with iron oxide nanoparticles, which enabled the noninvasive detection of the iron-labeled T cells with magnetic resonance imaging, photoacoustic imaging, and magnetic particle imaging.

CoVac501, a Self-Adjuvanting Peptide Vaccine Conjugated with TLR7 Agonists, against SARS-CoV-2 Induces Protective Immunity

[Cell Discovery] In non-human primates, CoVac501 elicited high and persistent titers of protective neutralizing antibodies against multiple receptor-binding domain mutations, SARS-CoV-2 original strain, and variants.

Immunosuppressive Features of the Microenvironment in Lymph Nodes Granulomas from Tuberculosis and HIV Co-Infected Patients

[American Journal of Pathology] Poorly formed necrotic tuberculosis (TB) granulomas containing a high expression of Mycobacterium tuberculosis antigens were elevated in TB/HIV co-infected lymph nodes, and inducible nitric oxide synthase as well as Arg-1 expression was significantly higher in TB/HIV co-infected compared to HIV-negative TB or control tissues.

Detection of the HIV-1 Accessory Proteins Nef and Vpu by Flow Cytometry Represents a New Tool to Study Their Functional Interplay within a Single...

[Journal of Virology] Researchers showed that the combined expression of Nef and Vpu predicted the susceptibility of HIV-1-infected primary CD4+ T cells to antibody-dependent cellular cytotoxicity by HIV+ plasma.

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