T cells

[NPJ Regenerative Medicine] Researchers developed an “off-the-shelf” adipose ECM biomaterial from allograft human tissue, applying physical and chemical processing methods to remove lipids and create an injectable matrix that mimicked the properties of lipoaspirate.

[World Journal of Surgical Oncology] CAR-T cell therapy and oncolytic viruses are innovative cancer therapeutic approaches with fewer complications than common treatments such as chemotherapy and radiotherapy and significantly improve the quality of life.

[Journal of Immunology] The authors integrated six bead-enriched T cell subsets with 62,235 single-cell transcriptomes from human PBMCs and clustered them into nine scRNA-seq clustered populations.

[Clinical & Translational Immunology] Investigators analyzed the frequency and functional profile of circulating and tumor-infiltrating mucosal-associated invariant T cells in human melanoma patients. Using flow cytometry, they compared these across metastatic sites and between ICI responders vs. non-responders as well as healthy donors.

[Oncogene] Scientists reported that both PD-L1 and JMJD2D were frequently overexpressed in human colorectal cancer specimens with a significant positive correlation.

[Annals of the Rheumatic Diseases] The crystal structures identified peptide binding to DRB1*04:01 and potential side chain exposure to T cells.