TFF1

[Biochemical Genetics] Circular RNA-trefoil factor 1 (circ-TFF1) and interleukin-1 receptor-associated kinase 1 (IRAK1) were significantly high expressed in breast cancer tissues and cells. Silencing of circ-TFF1 reduced the proliferation, migration, invasion and tube formation, while increased the apoptosis of MDA-MB-361 and SK-Br-3 cells.

[Experimental Eye Research] Researchers generated a diabetic retinopathy (DR) animal model using mice and a cell model in mouse retinal microvascular endothelial cells to examine the role of Trefoil factor family 1 in DR.

[Pathology Research and Practice] Recent investigations have shown the crucial effects of circrRNAs in the evolution of breast cancer. The authors explore the results of researches that appraised the role of circRNAs in breast cancer.