Cardiovascular Disease Risk Factors Induce Mesenchymal Features and Senescence in Mouse Cardiac Endothelial Cells

Scientists applied florescence-activated cell sorting, RNA sequencing and bioinformatic methods to investigate the common effects of cardiovascular disease risk factors in mouse cardiac endothelial cells.
[eLife]
Hemanthakumar, K. A., Fang, S., Anisimov, A., Mäyränpää, M. I., Mervaala, E., & Kivelä, R. (2021). Cardiovascular disease risk factors induce mesenchymal features and senescence in mouse cardiac endothelial cells. ELife, 10, e62678. https://doi.org/10.7554/eLife.62678 Cite
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Adaptive T-Cell Immunity Controls Senescence-Prone MyD88- or CARD11-Mutant B-Cell Lymphomas

Scientists functionally investigate primary mouse lymphomas that formed in recipient mice of Eµ-myc transgenic hematopoietic stem cells stably transduced with naturally occurring NF-kB mutants.
[Blood]
Reimann, M., Schrezenmeier, J. F., Richter-Pechanska, P., Dolnik, A., Hick, T. P., Schleich, K., Cai, X., Fan, D. N. Y., Lohneis, P., Masswig, S., Denker, S., Busse, A., Knittel, G., Flümann, R., Childs, D., Childs, L., Gätjens-Sanchez, A. M., Bullinger, L., Rosenwald, A., … Schmitt, C. A. (n.d.). Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas. Blood. https://doi.org/10.1182/blood.2020005244 Cite
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In Well-Differentiated Primary Human Bronchial Epithelial Cells, TGF-β1 and TGF-β2 Induce Expression of Furin

Investigators assessed the suitability of primary human bronchial epithelial cells maintained in air-liquid interface as an experimental system for studying SARS-CoV-2 infection in vitro.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]
O’Sullivan, M. J., Mitchel, J. A., Mwase, C., McGill, M., Kanki, P., & Park, J.-A. (2020). In well-differentiated primary human bronchial epithelial cells, TGF-β1 and TGF-β2 induce expression of furin. American Journal of Physiology-Lung Cellular and Molecular Physiology. https://doi.org/10.1152/ajplung.00423.2020 Cite
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Isoliquiritigenin Inhibits TGF-β1-Induced Fibrogenesis through Activating Autophagy via PI3K/AKT/mTOR Pathway in MRC-5 Cells

Investigators aimed to explore the roles and the underlying mechanisms of Isoliquiritigenin in TGF-β1-induced fibrogenesis using human lung fibroblast-derived MRC-5 cells.
[Acta Biochimica et Biophysica Sinica]
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A Pygopus 2-Histone Interaction Is Critical for Cancer Cell De-Differentiation and Progression in Malignant Breast Cancer

Investigators demonstrated that the histone binding function of Pygo2 was important for driving de-differentiation and malignancy of breast tumors, and loss of this binding activated various differentiation pathways which attenuated primary tumor growth and metastasis formation.
[Cancer Research]
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A Novel Mitochondrial Targeted Hybrid Peptide Modified HPMA Copolymers for Breast Cancer Metastasis Suppression

Researchers designed a mitochondrial targeted drug delivery system based on N-(2-hydroxypropyl) methacrylamide copolymers to simultaneously inhibit breast cancer progression and metastasis.
[Journal of Controlled Release]
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TNF Deficiency Dysregulates Inflammatory Cytokine Production, Leading to Lung Pathology and Death during Respiratory Poxvirus Infection

Tumor necrosis factor (TNF) deficiency did not affect viral load or leukocyte recruitment but caused severe lung pathology and excessive production of the cytokines interleukin (IL)-6, IL-10, transforming growth factor beta, and interferon gamma
[Proceedings of the National Academy of Sciences of the United States of America]
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Lineage Reversion Drives WNT Independence in Intestinal Cancer

Scientists showed that while WNT suppression blocked tumor growth in most organoid and in vivo colorectal cancer (CRC) models, the accumulation of CRC-associated genetic alterations enabled drug resistance and WNT-independent growth.
[Cancer Discovery]
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NRP2 as an Emerging Angiogenic Player; Promoting Endothelial Cell Adhesion and Migration by Regulating Recycling of α5 Integrin

The authors demonstrated that neuropilin (NRP)2 promoted Rac-1 mediated endothelial cell adhesion and migration over fibronectin matrices in a mechanistically distinct fashion to NRP1, showing no dependence on β3 integrin expression, or VEGF stimulation
[Frontiers in Cell and Developmental Biology]
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