TGF-B

[eLife] Scientists applied florescence-activated cell sorting, RNA sequencing and bioinformatic methods to investigate the common effects of cardiovascular disease risk factors in mouse cardiac endothelial cells.

[Blood] Scientists functionally investigate primary mouse lymphomas that formed in recipient mice of Eµ-myc transgenic hematopoietic stem cells stably transduced with naturally occurring NF-kB mutants.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Investigators assessed the suitability of primary human bronchial epithelial cells maintained in air-liquid interface as an experimental system for studying SARS-CoV-2 infection in vitro.

[Acta Biochimica et Biophysica Sinica] Investigators aimed to explore the roles and the underlying mechanisms of Isoliquiritigenin in TGF-β1-induced fibrogenesis using human lung fibroblast-derived MRC-5 cells.

[Cancer Research] Investigators demonstrated that the histone binding function of Pygo2 was important for driving de-differentiation and malignancy of breast tumors, and loss of this binding activated various differentiation pathways which attenuated primary tumor growth and metastasis formation.

[Journal of Controlled Release] Researchers designed a mitochondrial targeted drug delivery system based on N-(2-hydroxypropyl) methacrylamide copolymers to simultaneously inhibit breast cancer progression and metastasis.