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Cardiovascular Disease Risk Factors Induce Mesenchymal Features and Senescence in Mouse Cardiac Endothelial Cells

[eLife] Scientists applied florescence-activated cell sorting, RNA sequencing and bioinformatic methods to investigate the common effects of cardiovascular disease risk factors in mouse cardiac endothelial cells.

Adaptive T-Cell Immunity Controls Senescence-Prone MyD88- or CARD11-Mutant B-Cell Lymphomas

[Blood] Scientists functionally investigate primary mouse lymphomas that formed in recipient mice of Eµ-myc transgenic hematopoietic stem cells stably transduced with naturally occurring NF-kB mutants.

In Well-Differentiated Primary Human Bronchial Epithelial Cells, TGF-β1 and TGF-β2 Induce Expression of Furin

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Investigators assessed the suitability of primary human bronchial epithelial cells maintained in air-liquid interface as an experimental system for studying SARS-CoV-2 infection in vitro.

Isoliquiritigenin Inhibits TGF-β1-Induced Fibrogenesis through Activating Autophagy via PI3K/AKT/mTOR Pathway in MRC-5 Cells

[Acta Biochimica et Biophysica Sinica] Investigators aimed to explore the roles and the underlying mechanisms of Isoliquiritigenin in TGF-β1-induced fibrogenesis using human lung fibroblast-derived MRC-5 cells.

A Pygopus 2-Histone Interaction Is Critical for Cancer Cell De-Differentiation and Progression in Malignant Breast Cancer

[Cancer Research] Investigators demonstrated that the histone binding function of Pygo2 was important for driving de-differentiation and malignancy of breast tumors, and loss of this binding activated various differentiation pathways which attenuated primary tumor growth and metastasis formation.

A Novel Mitochondrial Targeted Hybrid Peptide Modified HPMA Copolymers for Breast Cancer Metastasis Suppression

[Journal of Controlled Release] Researchers designed a mitochondrial targeted drug delivery system based on N-(2-hydroxypropyl) methacrylamide copolymers to simultaneously inhibit breast cancer progression and metastasis.