UC-MSCs

[International Immunopharmacology] Human umbilical cord mesenchymal stem cells were used to deliver reovirus using in vitro and in vivo models.

[Stem Cell Research & Therapy] In this Phase I clinical trial, researchers present the safety, feasibility, and tolerability of the multiple infusions of high dose MSCs, which originated from the placenta and umbilical cord, in critically ill COVID-19-induced acute respiratory distress syndrome (ARDS) patients.

[Stem Cell Research & Therapy] Doxorubicin, a commonly used chemotherapy drug, was used to treat human umbilical cord-derived MSCs for six hours as an in vitro cell model of chemotherapy-induced damage.

[Stem Cells and Development] When human umbilical cord MSCs were transplanted directly, only a minority of cells migrated toward damaged tissues. Moreover, their maintenance time was short, leading to unsatisfactory therapeutic results.

[Stem Cell Research & Therapy] Scientists investigated freshly isolated, uncultured umbilical cord (UC)-MSCs by single-cell RNA sequencing and found two populations of UC-MSCs.

[Stem Cell Research & Therapy] Human umbilical cord-derived mesenchymal stem cells were successfully cultured and identified, and exosomes were isolated from the supernatant by ultracentrifugation.