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[Tempest Therapeutics, Inc.] Tempest Therapeutics, Inc. announced the first patient has been dosed in the global randomized Phase Ib/II clinical study evaluating TPST-1120, Tempest’s small molecule PPAR⍺ antagonist, in combination with the standard-of-care regimen of atezolizumab and bevacizumab in the first-line treatment of patients with advanced or metastatic hepatocellular carcinoma.

[Antioxidants & Redox Signaling] Researchers examined the hematopoietic versus non-hematopoietic role of p66Shc in regulating hematopoietic stem/progenitor cells traffic and blood flow recovery after ischemia in diabetic mice.

[Phytotherapy Research] Scientists analyzed the inhibitory effects of AA on angiogenesis using HUVECs cultured in vitro and on the growth and metastasis of a subcutaneous breast cancer 4T1 tumor model and a lung metastasis model in vivo.

[Scientific Reports] The authors previously remodeled the ECM hydrogel that enhanced the tight barrier formation of 3D blood vessels and the vascular endothelial growth factor gradient induced angiogenesis in a microfluidic device. In this study, the blood vessel model was further introduced to understand how gamma irradiation affected the endothelial monolayer.

[Cell Death & Disease] Rheumatoid arthritis synovial fluid increased endothelial progenitor cell homing and angiogenesis, which was blocked by the CXCL13 antibody.

[Stem Cells and Development] Investigators explored the protective benefit of heme oxygenase-1-placenta-derived MSC transplantation in a preeclampsia-like rat model.