YAP

[Nature Communications] Scientists demonstrated that healthy and idiopathic pulmonary fibrosis (IPF) airway epithelia were biophysically distinct, identifying pathologic activation of the ERBB-YAP axis as a specific and modifiable driver of prolongation of the unjammed-to-jammed transition in IPF epithelia.

[Stem Cells and Development] Scientists reported that reduced death-associated protein kinase 1 (DAPK1) expression promoted stem cell-like characteristics of prostate cancer cells through activating zinc finger E-box binding homeobox-1 (ZEB1) via Hippo/YAP signaling pathway.

[Clinical Cancer Research] Scientists performed transcriptional profiling of tumors from a Phase II clinical trial of platinum chemotherapy for advanced TNBC, revealing a gene expression signature that identified de novo chemorefractory tumors.

[Nature Communications] SNO-GNAI2 acted by coupling with CXCR5 to dephosphorylate the Hippo pathway kinase LATS1, thereby leading to nuclear translocation of YAP and promoting an inflammatory response in endothelial cells.

[Cell Reports] Through in vivo lineage tracing and in vitro molecular experiments, scientists revealed that reduced YAP/TAZ activity promoted intrinsic goblet transdifferentiation of secretory airway epithelial cells.

[Nature Communications] Researchers showed that cell sensing of external forces and of passive mechanical parameters could be understood through mechanisms, driven by the properties under force of the mechanosensing molecules involved.