acinar cells

[Autoimmunity] Cerulean and LPS was used to establish a rat model and an in vitro model of severe acute pancreatitis. qRT-PCR, western blot and IHC were determined to analyse the expression of mRNA and proteins. IL-1β, TNF-α and IL-6 levels were measured applying ELISA.

[Gastroenterology] Pancreas-specific Agr2 ablation was performed to access its role in pancreatic carcinogenesis. Hydrophobic hexapeptides loaded in liposomes were developed to disrupt Agr2-RNAPII complex.

[Cancer Letters] Scientists investigated the role of ANGPTL4 in KRASG12D-induced acinar-to-ductal metaplasia, pancreatic intraepithelial neoplasia formation, and pancreatic ductal adenocarcinoma maintenance.

[Nature Communications] In isolated pancreatic acinar cells, insulin induced Akt-mediated phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2) which upregulated glycolysis thereby preventing POA-induced ATP depletion.

[Cell Death & Disease] The pancreas was analyzed by histology, immunochemistry staining, and TUNEL assays, and the expression of certain proteins and RNAs, cytokine levels, trypsin activity, and reactive oxygen species (ROS) levels were determined.

[Cell Death & Disease] Researchers found that Ripk3−/− mice had significantly more severe pancreatic edema and inflammation associated with macrophage and neutrophil infiltration than control mice.