acinar cells

[Scientific Reports] Scientists provide a new cellular narrative for pancreatic development, homeostasis and response to injury via a small SETD4+ cell population.

[Cancer Research] Scientists re-analyzed multiple pancreas and pancreatic ductal adenocarcinoma single-cell RNA-seq datasets and found a subset of non-malignant acinar cells, which they refered to as acinar edge (AE) cells, whose transcriptomes highly diverged from a typical acinar cell in each dataset.

[Cell Metabolism] Researchers describe the detection of SARS-CoV-2 viral antigen in pancreatic beta cells in autopsy samples from individuals with COVID-19.

[Physiological Reviews] Researchers elucidate the roles of calcium and ATP in the control of the normal functions of the different cell types in the exocrine pancreas as well as the roles of these molecules in the pathophysiology of Acute Pancreatitis.

[Molecular Oncology] Scientists found that genetic deficiency for protease‐activated receptor 1(PAR1) increases acinar gene expression programs in the healthy pancreas and that PAR1 deficiency limits ductal transdifferentiation in experimental systems for acinar‐to‐ductal metaplasia.

[Cell Death & Differentiation] The authors applied a non-genetic lineage tracing method of human pancreatic exocrine acinar and duct cells that allowed cell-type-specific gene expression profiling by RNA sequencing.