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acute lung injury

Constitutive Transgenic Alpha-Klotho Overexpression Enhances Resilience to and Recovery from Murine Acute Lung Injury

[American Journal of Physiology-Lung Cellular and Molecular Physiology] A549 lung epithelial cells transfected with Klotho cDNA or vector were exposed to cigarette smoke; lactate dehydrogenase and double-strand DNA breaks were measured.

Plasma Extracellular Vesicle Delivery of miR-210-3p by Targeting ATG7 to Promote Sepsis-Induced Acute Lung Injury by Regulating Autophagy and Activating Inflammation

[Experimental & Molecular Medicine] Scientists elucidated the role of plasma extracellular vesicles in delivering miR-210-3p in sepsis-induced acute lung injury.

Bracing NK Cell Based Therapy to Relegate Pulmonary Inflammation in COVID-19

[Heliyon] Investigators discuss the possible use of natural killer (NK) cells cells as a therapeutic agent in view of preventing immunological harms of SARS-CoV-2 and the current challenges in advocating NK cell therapy for the same.

ZFP36 Protects Lungs from Intestinal I/R-Induced Injury and Fibrosis through the CREBBP/p53/p21/Bax Pathway

[Cell Death & Disease] Researchers investigated the involvement of zinc finger protein 36 (ZFP36) and cAMP‐response element-binding protein binding protein (CREBBP) on ischemia–reperfusion (I/R)-induced lung injury in vivo and in vitro.

Inhibition of miR-1298-5p Attenuates Sepsis Lung Injury by Targeting SOCS6

[Molecular and Cellular Biochemistry] miR-1298-5p and suppressor of cytokine signaling 6 (SOCS6) were silenced or overexpressed in human bronchial epithelial cells. PKH-67 Dye was used to trace exosome endocytosis.

Angiopoietin-1 Protects against Endotoxin-Induced Neonatal Lung Injury and Alveolar Simplification in Mice

[Pediatric Research] Researchers hypothesized that recombinant angiopoietin 1 will mitigate sepsis-induced angiopoietin 2 expression, inflammation, acute lung injury, and alveolar remodeling in the saccular lung.

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