Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsmiR-1298-5p and suppressor of cytokine signaling 6 (SOCS6) were silenced or overexpressed in human bronchial epithelial cells. PKH-67 Dye was used to trace exosome endocytosis.
[Molecular and Cellular Biochemistry]
7753456 725NBQHZ items 1 apa 0 default asc 1 163279 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-3eab3252e7096512f225e57e13c9c7d3%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22725NBQHZ%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ma%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-07%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMa%2C%20J.%2C%20Xu%2C%20L.-Y.%2C%20Sun%2C%20Q.-H.%2C%20Wan%2C%20X.-Y.%2C%20%26amp%3B%20BingLi.%20%282021%29.%20Inhibition%20of%20miR-1298-5p%20attenuates%20sepsis%20lung%20injury%20by%20targeting%20SOCS6.%20%3Ci%3EMolecular%20and%20Cellular%20Biochemistry%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs11010-021-04170-w%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs11010-021-04170-w%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3D725NBQHZ%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Inhibition%20of%20miR-1298-5p%20attenuates%20sepsis%20lung%20injury%20by%20targeting%20SOCS6%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jian%22%2C%22lastName%22%3A%22Ma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Li-Yun%22%2C%22lastName%22%3A%22Xu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qiu-Hong%22%2C%22lastName%22%3A%22Sun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiao-Yu%22%2C%22lastName%22%3A%22Wan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22BingLi%22%7D%5D%2C%22abstractNote%22%3A%22Sepsis%20is%20one%20of%20the%20leading%20causes%20of%20morbidity%20and%20mortality%20and%20a%20major%20cause%20of%20acute%20lung%20injury%20%28ALI%29.%20carried%20by%20exosomes%20play%20a%20role%20in%20a%20variety%20of%20diseases.%20However%2Cthere%20are%20not%20many%20studies%20of%20exosomal%20miRNAs%20in%20sepsis%20and%20sepsis%20lung%20injury.miR-1298-5p%20and%20suppressor%20of%20cytokine%20signaling%206%20%28SOCS6%29%20were%20silenced%20or%20overexpressed%20in%20human%20bronchial%20epithelial%20cells%20%28BEAS-2B%29.%20PKH-67%20Dye%20was%20used%20to%20trace%20exosome%20endocytosis.%20Cell%20permeability%20was%20evaluated%20by%20measuring%20trans-epithelial%20electrical%20resistance%20%28TEER%29%20and%20FITC%20dextran%20flux.%20ELISA%20kits%20were%20used%20for%20cytokine%20detection.%20Quantitative%20RT-PCR%20and%20western%20blots%20were%20used%20to%20evaluate%20gene%20expression.%20miR-1298-5p%20was%20elevated%20in%20exosomes%20from%20patients%20with%20sepsis%20lung%20injury%20%28Sepsis_exo%29.%20Treatment%20of%20BEAS-2B%20cells%20using%20Sepsis_exo%20significantly%20inhibited%20cell%20proliferation%2C%20and%20induced%20cell%20permeability%20and%20inflammatory%20response.%20miR-1298-5p%20directly%20targeted%20SOCS6.%20Overexpressing%20SOCS6%20reversed%20miR-1298-5p-induced%20cell%20permeability%20and%20inflammatory%20response.%20Inhibition%20of%20STAT3%20blocked%20SOCS6-silencing%20caused%20significant%20increase%20of%20cell%20permeability%20and%20inflammation.%20Exosomes%20isolated%20from%20patients%20of%20sepsis%20lung%20injury%20increased%20cell%20permeability%20and%20inflammatory%20response%20in%20BEAS-2B%20cells%20through%20exosomal%20miR-1298-5p%20which%20targeted%20SOCS6%20via%20STAT3%20pathway.%20The%20findings%20highlight%20the%20importance%20of%20miR-1298-5p%5C%2FSOCS6%5C%2FSTAT3%20axis%20in%20sepsis%20lung%20injury%20and%20provide%20new%20insights%20into%20therapeutic%20strategies%20for%20sepsis%20lung%20injury.%22%2C%22date%22%3A%222021-06-07%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs11010-021-04170-w%22%2C%22ISSN%22%3A%221573-4919%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs11010-021-04170-w%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-10T19%3A14%3A20Z%22%7D%7D%5D%7D
Ma, J., Xu, L.-Y., Sun, Q.-H., Wan, X.-Y., & BingLi. (2021). Inhibition of miR-1298-5p attenuates sepsis lung injury by targeting SOCS6. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-021-04170-w Cite
