CCCTC-Binding Factor Transcriptionally Regulates Galectin-7 and Activates the JNK/STAT3 Axis to Aggravate Bronchial Epithelial Cell Injury

Human bronchial epithelial cells BEAS-2B were stimulated with transforming growth factor-β1 at a concentration of 10 ng/mL, and CCCTC-binding factor (CTCF) overexpression plasmid and CTCF small interfering RNA were transfected into the cells.
[Pediatric Pulmonology]
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Culture with Apically Applied Healthy or Disease Sputum Alters the Airway Surface Liquid Proteome and Ion Transport across Human Bronchial Epithelial Cells.

Researchers investigated how culture of normal human bronchial epithelial cells with apically applied secretions from healthy or disease lungs affected epithelial function with a view to providing better in vitro models of the in vivo environment.
[American Journal of Physiology-Cell Physiology]
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Inhaled Sphingosine Has No Adverse Side Effects in Isolated Ventilated and Perfused Pig Lungs

Scientists tested whether sphingosine has any adverse effects in the respiratory tract when applied into isolated ventilated and perfused lungs. A four hour ex vivo lung perfusion run using minipig lungs was performed.
[Scientific Reports]
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Escherichia coli Infection Activates the Production of IFN-α and IFN-β via the JAK1/STAT1/2 Signaling Pathway in Lung Cells

Researchers studied whether E. coli infections could regulate interferon production and the underlying mechanisms. Two lung cell lines, a human bronchial epithelial cell line transformed with Ad12-SV40 2B and a human fetal lung fibroblast cell line, were used.
[Amino Acids]
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Down-Regulation of lncRNA MEG3 Promotes Chronic Low Dose Cadmium Exposure-Induced Cell Transformation and Cancer Stem Cell-Like Property

The long non-coding RNA microarray analysis showed that the expression level of a tumor suppressive lncRNA maternally expressed 3 was significantly down-regulated in cadium-transformed cells, which was confirmed by further q-PCR analysis.
[Toxicology and Applied Pharmacology]
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Serum-Derived Exosomes from House Dust Mite-Sensitized Guinea Pigs Contribute to Inflammation in BEAS-2B Cells via the TLR4-NF-κB Pathway

The authors investigated whether serum exosomes played a pro‑inflammatory role in bronchial epithelial cells and explored the underlying molecular mechanisms.
[Molecular Medicine Reports]
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Anti-inflammatory Actions of Aspirin-Triggered Resolvin D1 (AT-RvD1) in Bronchial Epithelial Cells Infected with Cryptococcus neoformans

The interaction of Cryptococcus neoformans with airway epithelial cells is crucial for the establishment of cryptococcosis. Scientists evaluated the effects of AT-RvD1 on human bronchial epithelial cells stimulated with C. neoformans.
[inflammopharmacology]
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Signaling Pathway Perturbation Analysis for Assessment of Biological Impact of Cigarette Smoke on Lung Cells

Investigators reported the development of an algorithm based on quantitative assessment of transcriptomic profiles and signaling pathway perturbation analysis of human bronchial epithelial cells exposed to the toxic components present in cigarette smoke.
[Scientific Reports]
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PGC-1α Mediates a Metabolic Host Defense Response in Human Airway Epithelium during Rhinovirus Infections

Researchers observed that early Human rhinoviruses (HRV)-C15 infection induced a transitory barrier-protective metabolic state characterized by glycolysis that ultimately became exhausted as the infection progresses and led to cellular damage.
[Nature Communications]
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Single-Cell RNA Sequencing Identify SDCBP in ACE2-Positive Bronchial Epithelial Cells Negatively Correlates with COVID-19 Severity

Since angiotensin-converting enzyme 2 (ACE2)-positive cells were hosts for COVID-19, researchers focussed on this cell type to explore the underlying mechanisms of COVID-19.
[Journal of Cellular and Molecular Medicine]
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HDAC4 Induces the Development of Asthma by Increasing Slug-Upregulated CXCL12 Expression through KLF5 Deacetylation

Researchers used asthma model bronchial smooth muscle cells to measure the biological behaviors of Histone deacetylase 4 (HDAC4)-mediated Kruppel-like factor 5 (KLF5)/Slug/CXC chemokine ligand-12 (CXCL12) axis on the development of asthma in regulation of airway inflammation and remodeling.
[Journal of Translational Medicine]
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