Researchers showed that miR-135a was aberrantly downregulated in non-small cell lung cancer (NSCLC) cells in comparison with normal bronchial epithelial cells, and the expression of miR-135a inhibited proliferation, invasion and metastasis of NSCLC cells in vitro.
Primary bronchial epithelial cells (mBECs) were extracted, and the expression of TGF signaling pathway‐, autophagy‐ and PI3K/Akt/mTOR signaling pathway‐related proteins in mBECs was detected by immunofluorescence assay and Western blot analysis.
[Journal of Cellular and Molecular Medicine]
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Cong, L.-H., Li, T., Wang, H., Wu, Y.-N., Wang, S.-P., Zhao, Y.-Y., … Duan, J. (n.d.). IL-17A-producing T cells exacerbate fine particulate matter-induced lung inflammation and fibrosis by inhibiting PI3K/Akt/mTOR-mediated autophagy. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.15475 Cite
The effects of indium oxide nanoparticles on lung cells associated with respiratory and immune barriers and the toxic effects of intercellular cascades were studied.
[Journal of Applied Toxicology]
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Indium oxide nanoparticles induce lung intercellular toxicity between bronchial epithelial cells and macrophages - Li - - Journal of Applied Toxicology - Wiley Online Library. (n.d.). Retrieved July 2, 2020, from https://onlinelibrary.wiley.com/doi/abs/10.1002/jat.4023 Cite
The concomitant activation of ferroptosis and autophagy by 15-lipoxygenase-1–PE-binding protein-1 complexes and their hydroperoxy-phospholipids revealed a pathobiologic pathway relevant to asthma and amenable to therapeutic targeting.
[Proceedings of the National Academy of Sciences of the United States of America]
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Researchers tested an antisense oligonucleotide targeting the cystic fibrosis (CF) transmembrane conductance regulator c.3718-2477C>T mutation and showed that it effectively blocks aberrant splicing in primary bronchial epithelial cells from CF patients with the mutation.
[Nucleic Acids Research]
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