Incense Smoke-Induced Oxidative Stress Disrupts Tight Junctions and Bronchial Epithelial Barrier Integrity and Induces Airway Hyperresponsiveness in Mouse Lungs

Using mouse and cell culture models, the authors evaluated the effects of incense smoke exposure on airway hyperresponsiveness, expression of multiple epithelial tight junction- and adherens junction-associated mRNAs and proteins in the lungs, and the barrier function of bronchial epithelial cells assessed by transepithelial electronic resistance.
[Scientific Reports]
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SARS-CoV-2 Variants Reveal Features Critical for Replication in Primary Human Cells

By integrating viral sequencing data from patient material, virus stocks, and passaging experiments, together with kinetic virus replication data from nonhuman Vero-CCL81 cells and primary differentiated human bronchial epithelial cells (BEpCs), scientists observed several SARS-CoV-2 features that associated with distinct phenotypes.
[PLOS Biology]
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Panaxydol Attenuates Ferroptosis against LPS-Induced Acute Lung Injury in Mice by Keap1-Nrf2/HO-1 Pathway

In vivo, the role of panaxydol (PX) on lipopolysaccharide (LPS)-induced acute lung injury in mice was tested by determination of LPS-induced pulmonary inflammation, pulmonary edema and ferroptosis. In vitro, BEAS-2B cells were used to investigate the molecular mechanisms by which PX functions via determination of inflammation, ferroptosis and their relationship.
[Journal of Translational Medicine]
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PGC-1α Regulates Airway Epithelial Barrier Dysfunction Induced by House Dust Mite

BEAS-2B cells were exposed to house dust mite and the expressions of PGC-1α and E-cadherin were examined by immunoblotting.
[Respiratory Research]
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Low-Dose Drosera rotundifolia Induces Gene Expression Changes in 16HBE Human Bronchial Epithelial Cells

The biological functions of D. rotundifolia were explored in vitro following the treatment of bronchial epithelial cells, which are the potential targets of the pharmacological effects of the herbal medicine.
[Scientific Reports]
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Outer Membrane Vesicles Derived from Klebsiella pneumoniae Influence the miRNA Expression Profile in Human Bronchial Epithelial BEAS-2B Cells

miRNA expression profiles in human bronchial epithelial cells were evaluated during infection with standard and clinical K. pneumoniae strains.
[Microorganisms]
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Geomagnetic Shielding Enhances Radiation Resistance by Promoting DNA Repair Process in Human Bronchial Epithelial Cells

Immortalized human bronchial epithelial cells were exposed to X-rays under either a geomagnetic field or hypomagnetic field (HMF) culture condition. A significant increase of the cell survival rate in HMF after radiation was observed by colony formation analysis.
[International Journal of Molecular Sciences]
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Enhancement of the IFN-β-induced host signature informs repurposed drugs for COVID-19

Researchers used a host-directed approach, which focused on cellular responses to diverse small-molecule treatments, to identify potentially effective drugs for COVID-19.
[Heliyon]
Huang, C.-T., Chao, T.-L., Kao, H.-C., Pang, Y.-H., Lee, W.-H., Hsieh, C.-H., Chang, S.-Y., Huang, H.-C., & Juan, H.-F. (2020). Enhancement of the IFN-β-induced host signature informs repurposed drugs for COVID-19. Heliyon, 0(0). https://doi.org/10.1016/j.heliyon.2020.e05646 Cite
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A Fusion of CD63–BCAR4 Identified in Lung Adenocarcinoma Promotes Tumorigenicity and Metastasis

Based on the analysis of RNA-sequencing data, investigators identified a fusion transcript of CD63–breast cancer anti-oestrogen-resistance 4 (BCAR4) in a Korean patient with lung adenocarcinoma who did not harbour any known activating mutations in EGFR and KRAS genes. To investigate the oncogenic effect of CD63–BCAR4, in vitro and in vivo animal experiments were performed.
[British Journal of Cancer]
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Altered Transcriptional and Chromatin Responses to Rhinovirus in Bronchial Epithelial Cells from Adults with Asthma

Scientists demonstrated that cultured primary bronchial epithelial cells from adults with asthma showed different transcriptional and chromatin responses to rhinovirus infection compared to those without asthma.
[Communications Biology]
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Additive Effects of Simulated Microgravity and Ionizing Radiation in Cell Death, Induction of ROS and Expression of RAC2 in Human Bronchial Epithelial Cells

Human lung bronchial epithelial Beas-2B cells were used to study the regulation of radiobiological effects by simulated microgravity. It was found that simulated microgravity together with radiation induced drop of survival fraction, proliferation inhibition, apoptosis, and DNA double-strand break formation of Beas-2B cells additively.
[NPJ Microgravity]
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