Based on the analysis of RNA-sequencing data, investigators identified a fusion transcript of CD63–breast cancer anti-oestrogen-resistance 4 (BCAR4) in a Korean patient with lung adenocarcinoma who did not harbour any known activating mutations in EGFR and KRAS genes. To investigate the oncogenic effect of CD63–BCAR4, in vitro and in vivo animal experiments were performed.
[British Journal of Cancer]
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Bae, K., Kim, J. H., Jung, H., Kong, S.-Y., Kim, Y.-H., Kim, S., Lee, G. K., Lee, J. S., Lee, J. J.-K., Ju, Y. S., Choi, Y.-K., & Yoon, K.-A. (2020). A fusion of CD63–BCAR4 identified in lung adenocarcinoma promotes tumorigenicity and metastasis. British Journal of Cancer, 1–9. https://doi.org/10.1038/s41416-020-01146-3 Cite
Scientists demonstrated that cultured primary bronchial epithelial cells from adults with asthma showed different transcriptional and chromatin responses to rhinovirus infection compared to those without asthma.
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Human lung bronchial epithelial Beas-2B cells were used to study the regulation of radiobiological effects by simulated microgravity. It was found that simulated microgravity together with radiation induced drop of survival fraction, proliferation inhibition, apoptosis, and DNA double-strand break formation of Beas-2B cells additively.
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Human bronchial epithelial cells BEAS-2B were exposed to standard reference material 1649b, followed by RNA-sequencing and a combination of different bioinformatics analysis.
[Environmental Science and Pollution Research]
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Investigators uncovered that ERK3, a ubiquitously expressed atypical MAPK, was required for KRAS-mediated NSCLC tumors. ERK3 is highly expressed in lung cancers, and oncogenic KRAS led to the activation and stabilization of the ERK3 protein.
[Cancer Gene Therapy]
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Scientists triggered partial epithelial-to-mesenchymal transition or unjamming transition in differentiated primary human bronchial epithelial cells.
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Mitchel, J. A., Das, A., O’Sullivan, M. J., Stancil, I. T., DeCamp, S. J., Koehler, S., Ocaña, O. H., Butler, J. P., Fredberg, J. J., Nieto, M. A., Bi, D., & Park, J.-A. (2020). In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition. Nature Communications, 11(1), 5053. https://doi.org/10.1038/s41467-020-18841-7 Cite
Scientists examined the role of Sprouty-related EVH-1-domain-containing protein (Spred) 2, a negative regulator of the MAPK-ERK pathway, in the development of bleomycin-induced pulmonary fibrosis.
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The authors investigated the dynamic toxicities of naphthalene-derived secondary organic aerosol in a human bronchial epithelial cell line and identified the chemical components responsible for toxicities.
[Proceedings of the National Academy of Sciences of the United States of America]
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Researchers used a randomized crossover experiment to estimate the effects of ozone exposure on genome-wide DNA methylation of target bronchial epithelial cells, using 17 volunteers, each randomly exposed on two separated occasions to clean air or 0.3-ppm ozone for two hours.
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The authors collected nasal cells by brushing to determine ionocyte abundance. Nasal and bronchial cells were also expanded in vitro and reprogrammed to differentiated epithelia for morphological and functional studies.
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Researchers investigated the roles of TRPA1 and TRPV3 in regulating endoplasmic reticulum stress and cytotoxicity in human bronchial epithelial cells treated with pneumotoxic wood smoke particulate matter and chemical agonists of each channel.
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