A Medium Composition Containing Normal Resting Glucose That Supports Differentiation of Primary Human Airway Cells

Investigators expanded and differentiated human basal cells isolated from the nasal and conducting airway to a mature mucociliary epithelial cell layer at air–liquid interface using a medium formulation containing normal resting glucose levels.
[Scientific Reports]
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Androgen Receptor Signaling Promotes Treg Suppressive Function during Allergic Airway Inflammation

Using androgen receptor (AR) deficient and Foxp3 fate-mapping mice, researchers determined that AR signaling increased Treg suppression during Alternaria extract challenge by stabilizing Foxp3+ Tregs and limiting the number of ST2+ ex-Tregs and IL-13+ Th2 and ex-Tregs.
[Journal of Clinical Investigation]
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Cryptococcus neoformans in Association with Dermatophagoides pteronyssinus Has Pro- (IL-6/STAT3 Overproduction) and Anti-inflammatory (CCL2/ERK1/2 Downregulation) Effects on Human Bronchial Epithelial Cells

The authors evaluated the effects of the association between Cryptococcus neoformans and Dermatophagoides pteronyssinus in the modulation of airway inflammatory responses in an in vitro experimental model using human bronchial epithelial cells.
[Inflammation]
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Metabolomic Dynamics of the Arsenic-Transformed Bronchial Epithelial Cells and the Derived Cancer Stem-Like Cells

By applying untargeted global metabolomics approach, the authors showed that arsenic was highly capable of perturbing the intracellular metabolic programs of the human bronchial epithelial cells, some of which were prominent hallmarks of cancer cell metabolism.
[International Journal of Biological Sciences]
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The Protective Effects of Omarigliptin against Lipopolysaccharide (LPS)- Induced Inflammatory Response and Expression of Mucin 5AC (MUC5AC) in Human Bronchial Epithelial Cells

Researchers investigated whether Omarigliptin possessed a beneficial effect against LPS-induced injuries in human BEAS-2B bronchial epithelial cells.
[Molecular Immunology]
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Budesonide Promotes Airway Epithelial Barrier Integrity Following Double-Stranded RNA Challenge

Researchers tested three classes of drugs commonly prescribed to treat asthma for their ability to promote barrier function using a cell culture model of virus-induced airway epithelial barrier disruption.
[PLoS One]
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In Vitro Evidence of the Influence of Complexation of Pu and Am on Uptake by Human Lung Epithelial Cells Calu-3

Investigators have evaluated in vitro the binding and uptake by bronchial epithelial cells Calu-3 of 2 transuranic actinides, plutonium (Pu) and americium (Am), as the first steps of translocation across the pulmonary barrier.
[Toxicology in Vitro]
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Smoking-Associated Upregulation of CBX3 Suppresses ARHGAP24 Expression to Activate Rac1 Signaling and Promote Tumor Progression in Lung Adenocarcinoma

Scientists explored the mechanisms regulating histone methylation in lung adenocarcinoma (LUAD) in response to smoking. They found that the histone H3K9 methylation reader CBX3 was upregulated in current smokers with LUAD, and that CBX3 overexpression promoted LUAD progression.
[Oncogene]
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HDAC8-Inhibitor PCI-34051-Induced Exosomes Inhibit Human Bronchial Smooth Muscle Cell Proliferation via miR-381-3p Mediated TGFB3

Researchers investigated the effects of PCI-34051-induced human bronchial epithelial cells-derived exosomes on human bronchial smooth muscle cells and the key exosomal miRNAs involved in this process.
[Pulmonary Pharmacology & Therapeutics]
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Role of Lysocardiolipin Acyltransferase in Cigarette Smoke-Induced Lung Epithelial Cell Mitochondrial ROS, Mitochondrial Dynamics, and Apoptosis

Researchers investigated the role of lysocardiolipin acyltransferase expression and activity in mitochondrial oxidative stress, mitochondrial dynamics, and lung epithelial cell apoptosis.
[Cell Biochemistry and Biophysics]
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CCCTC-Binding Factor Transcriptionally Regulates Galectin-7 and Activates the JNK/STAT3 Axis to Aggravate Bronchial Epithelial Cell Injury

Human bronchial epithelial cells BEAS-2B were stimulated with transforming growth factor-β1 at a concentration of 10 ng/mL, and CCCTC-binding factor (CTCF) overexpression plasmid and CTCF small interfering RNA were transfected into the cells.
[Pediatric Pulmonology]
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