A PI3Kγ Mimetic Peptide Triggers CFTR Gating, Bronchodilation, and Reduced Inflammation in Obstructive Airway Diseases

In human bronchial epithelial cells, phosphoinositide 3-kinase γ (PI3Kγ) mimetic peptide induced unexpected cyclic adenosine monophosphate and protein kinase A elevations restricted to the vicinity of the cystic fibrosis transmembrane conductance regulator (CFTR), the ion channel controlling mucus hydration that is mutated in CF.