CCCTC-Binding Factor Transcriptionally Regulates Galectin-7 and Activates the JNK/STAT3 Axis to Aggravate Bronchial Epithelial Cell Injury

Human bronchial epithelial cells BEAS-2B were stimulated with transforming growth factor-β1 at a concentration of 10 ng/mL, and CCCTC-binding factor (CTCF) overexpression plasmid and CTCF small interfering RNA were transfected into the cells.
[Pediatric Pulmonology]
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Eosinophil Extracellular Traps Drive Asthma Progression through Neuro-Immune Signals

Scientists showed that eosinophil extracellular traps in bronchoalveolar lavage fluid are associated with the severity of asthma in patients.
[Nature Cell Biology]
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RSV Infection-Elicited High MMP-12–Producing Macrophages Exacerbate Allergic Airway Inflammation with Neutrophil Infiltration

Scientists showed that RSV-induced alveolar macrophages, which produced high levels of matrix metalloproteinase-12, exacerbated allergic airway inflammation with increased neutrophil infiltration.
[iScience]
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Early Life Exposure to House Dust Mite Allergen Prevents Experimental Allergic Asthma Requiring Mitochondrial H2O2

Lung dendritic cells (DCs) from tolerized mice induced a low Th2 response in vitro mirroring impact of tolerance in vivo. Wild type-Tol mice displayed a decrease in total, cDC1 and cDC2 subsets in the lung as compared to that in naive mice.
[Mucosal Immunology]
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Mitogen-Activated Protein Kinase Signaling in Childhood Asthma Development and Environment-Mediated Protection

Scientists aimed to investigate the role of MAPK signaling in childhood asthma and its environment-mediated protection, including a representative selection of 232 out of 1062 children from two cross-sectional cohorts and one birth cohort study.
[Pediatric Allergy and Immunology]
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Serum-Derived Exosomes from House Dust Mite-Sensitized Guinea Pigs Contribute to Inflammation in BEAS-2B Cells via the TLR4-NF-κB Pathway

The authors investigated whether serum exosomes played a pro‑inflammatory role in bronchial epithelial cells and explored the underlying molecular mechanisms.
[Molecular Medicine Reports]
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TIPE2 Inhibits PDGF-BB-Induced Phenotype Switching in Airway Smooth Muscle Cells through the PI3K/Akt Signaling Pathway

Researchers explored the role of tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) in the regulation of airway smooth muscle cells, which are one of the main effector cells in the development of asthma.
[Respiratory Research]
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Amygdalin Attenuates Airway Epithelium Apoptosis, Inflammation, and Epithelial-Mesenchymal Transition through Restraining the TLR4/NF-κB Signaling Pathway on LPS-Treated BEAS-2B Bronchial Epithelial Cells

Cough-variant asthma (CVA) is a special type of asthma, solely manifesting with coughing. Investigators suggested that airway inflammation was associated with CVA pathogenesis.
[International Archives of Allergy and Immunology]
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Advances and Highlights in Asthma in 2021

Recently published articles and clinical trials are summarised and discussed with the goal to provide clinicians and researchers with a concise update on asthma research from a translational perspective.
[Allergy]
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Maternal Immune Activation and Neuroinflammation in Human Neurodevelopmental Disorders

The authors focus on the emerging human evidence for an association between maternal immune activation and childhood neurodevelopmental disorders, including autism spectrum disorder, attention-deficit/hyperactivity disorder and Tourette syndrome.
[Nature Reviews Neurology]
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Poly-L-Arginine Promotes Asthma Angiogenesis through Induction of FGFBP1 in Airway Epithelial Cells via Activation of the mTORC1-STAT3 Pathway

Scientists demonstrated that fibroblast growth factor-binding protein 1 was dramatically upregulated in airway epithelial cell lines treated by poly-L-arginine, a mimic of major basic protein.
[Cell Death & Disease]
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