FGL1 Regulates Acquired Resistance to Gefitinib by Inhibiting Apoptosis in Non-Small Cell Lung Cancer

Scientists investigated the role of fibrinogen-like protein 1 (FGL1) in regulating gefitinib resistance of PC9/GR non-small cell lung cancer.
[Respiratory Research]
Sun, C., Gao, W., Liu, J., Cheng, H., & Hao, J. (2020). FGL1 regulates acquired resistance to Gefitinib by inhibiting apoptosis in non-small cell lung cancer. Respiratory Research, 21(1), 210. https://doi.org/10.1186/s12931-020-01477-y Cite
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DRP1 Promotes Lactate Utilization in KRAS‐Mutant Non‐Small Cell Lung Cancer Cells

Scientists developed a lactate‐dependent cell proliferation assay and found that dynamin‐related protein (DRP1), which was highly expressed in KRAS‐mutant non‐small cell lung cancer (NSCLC), was required for tumor cells to proliferate and uses lactate as fuel, demonstrating the critical role of DRP1 in the metabolic reprogramming of NSCLC.
[Cancer Science]
Hu, M., Zhao, Y., Cao, Y., Tang, Q., Feng, Z., Ni, J., & Zhou, X. (n.d.). DRP1 promotes lactate utilization in KRAS-mutant non-small cell lung cancer cells. Cancer Science, n/a(n/a). https://doi.org/10.1111/cas.14603 Cite
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Neutrophil Extracellular Traps Amplify Neutrophil Recruitment and Inflammation in Neutrophilic Asthma by Stimulating the Airway Epithelial Cells to Activate the TLR4/NF-κB Pathway and Secrete Chemokines

Formation of neutrophil extracellular traps (NETs) and neutrophil swarming was seen in a mouse model of neutrophilic asthma. Additionally, NETs were found to stimulate airway cells to express CXCL1, CXCL2, and CXCL8 via the TLR4/NF-κB pathway, which recruits neutrophils to the inflammation site.
[Aging]
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Inhibitory Effect of MicroRNA-608 on Lung Cancer Cell Proliferation, Migration, and Invasion by Targeting BRD4 through the JAK2/STAT3 Pathway

Investigators determined the fundamental mechanism of microRNA-608 in the development of lung cancer.
[Bosnian Journal of Basic Medical Sciences]
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miR-135a Inhibits Non-Small Cell Lung Cancer Progression by Suppressing RAB1B Expression and the RAS Pathway

Researchers showed that miR-135a was aberrantly downregulated in non-small cell lung cancer (NSCLC) cells in comparison with normal bronchial epithelial cells, and the expression of miR-135a inhibited proliferation, invasion and metastasis of NSCLC cells in vitro.
[Aging]
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Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence

Researchers investigated whether the pharmacological sirtuin 1 activator SRT2104 protects against Type II alveolar epithelial cell senescence in rats with emphysema.
[COPD-Journal of Chronic Obstructive Pulmonary Disease]
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Ubiquilin Proteins Regulate EGFR Levels and Activity in Lung Adenocarcinoma Cells

The authors investigated a link between ubiquilin and the oncogene epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells.
[Journal of Cellular Biochemistry]
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