Lung Epithelial and Endothelial Damage, Loss of Tissue Repair, Inhibition of Fibrinolysis, and Cellular Senescence in Fatal COVID-19

Lung autopsy samples from 18 patients with fatal COVID-19, with symptom onset-to-death times ranging from 3 to 47 days, and antemortem plasma samples from 6 of these cases were evaluated using deep sequencing of SARS-CoV-2 RNA, multiplex plasma protein measurements, and pulmonary gene expression and imaging analyses.
[Science Translational Medicine]
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LINC00662: A New Oncogenic lncRNA with Great Potential

LINC00662 can reduce the promoter methylation level of s-adenosylmethionine-dependent hepatocellular carcinoma-promoting genes by regulating the MAT1A/SAM and AHCY/SAH axes, thereby promoting the activation of oncogenes. Scientists summarize the molecular regulation mechanism of LINC00662.
[Journal of Cellular Physiology]
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CCCTC-Binding Factor Transcriptionally Regulates Galectin-7 and Activates the JNK/STAT3 Axis to Aggravate Bronchial Epithelial Cell Injury

Human bronchial epithelial cells BEAS-2B were stimulated with transforming growth factor-β1 at a concentration of 10 ng/mL, and CCCTC-binding factor (CTCF) overexpression plasmid and CTCF small interfering RNA were transfected into the cells.
[Pediatric Pulmonology]
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In Vitro Genotoxicity of Dibutyl Phthalate on A549 Lung Cells at Air-Liquid Interface in Exposure Concentrations Relevant at Workplaces

While in vitro studies were often based on submerged exposures, this study aimed to expose A549 alveolar epithelial cells at the air-liquid interface (ALI) to unravel the genotoxic and oxidative stress-inducing potential of dibutyl phthalate (DBP) with concentrations relevant at occupational settings.
[Environmental and Molecular Mutagenesis]
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MYH9 Is Crucial for Stem Cell-Like Properties in Non-Small Cell Lung Cancer by Activating mTOR Signaling

The authors found that the stemness characteristics of lung cancer cells were significantly enhanced by the overexpression of non-muscle myosin heavy chain 9 (MYH9), and the knockout of MYH9 had the opposite effects.
[Cell Death Discovery]
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Protective Effect of Xiao-Xu-Ming Decoction-Mediated Inhibition of ROS/NLRP3 Axis on Lipopolysaccharide-Induced Acute Lung Injury In Vitro and In Vivo

As a traditional Chinese medicine prescription, Xiao-Xu-Ming decoction (XXMD) could reduce the incidence of lung infection of patients with cerebral infarction. In vitro, human pulmonary alveolar epithelial cells were treated with XXMD and were followed by lipopolysaccharide treatment.
[Evidence-Based Complementary and Alternative Medicine]
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Culture with Apically Applied Healthy or Disease Sputum Alters the Airway Surface Liquid Proteome and Ion Transport across Human Bronchial Epithelial Cells.

Researchers investigated how culture of normal human bronchial epithelial cells with apically applied secretions from healthy or disease lungs affected epithelial function with a view to providing better in vitro models of the in vivo environment.
[American Journal of Physiology-Cell Physiology]
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ERRFI1 Induces Apoptosis of Hepatocellular Carcinoma Cells in Response to Tryptophan Deficiency

The authors showed that ERRFI1 was upregulated in sensitive hepatocellular carcinoma (HCC) cells, but not in resistant HCC cells, in response to tryptophan deficiency, and ERRFI1 expression level positively correlated with HCC patient overall survival.
[Cell Death Discovery]
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Cancer Cells with Defective RB and CDKN2A Are Resistant to the Apoptotic Effects of Rapamycin

Scientists observed that DU145 prostate and NCI–H2228 lung cancer cells were resistant to the cytotoxic effect of rapamycin.
[Cancer Letters]
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Autophagic Secretion of HMGB1 from Cancer-Associated Fibroblasts Promotes Metastatic Potential of Non-Small Cell Lung Cancer Cells via NFκB Signaling

Researchers reported that autophagy was upregulated in lung cancer-associated cancer-associated fibroblasts (CAFs) compared to normal fibroblasts, and autophagy was responsible for the promoting effect of CAFs on non-small cell lung cancer cell migration and invasion.
[Cell Death & Disease]
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MRTF-a-NF-κB/p65 Axis-Mediated PDL1 Transcription and Expression Contributes to Immune Evasion of Non-Small-Cell Lung Cancer via TGF-β

Researchers defined a new signaling pathway that regulated the transcription and expression of PD-L1 upon TGF-β treatment, which might have a significant impact on research into the application of immunotherapy in treating lung cancer.
[Experimental and Molecular Medicine]
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