Investigators showed that paclitaxel-resistant H460 lung cancer cells, generated by a stepwise increase in paclitaxel, exhibited markedly increased tubulin acetylation and consequently acquired paclitaxel resistance.
[Cell Death Discovery]
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Wattanathamsan, O., Thararattanobon, R., Rodsiri, R., Chanvorachote, P., Vinayanuwattikun, C., & Pongrakhananon, V. (2021). Tubulin acetylation enhances lung cancer resistance to paclitaxel-induced cell death through Mcl-1 stabilization. Cell Death Discovery, 7(1), 1–13. https://doi.org/10.1038/s41420-021-00453-9 Cite
Researchers performed loss and gain of function experiments for the expression of miR-499 in lung cancer cells exposed to irradiation to determine the effect of miR-499 expression on cell viability and apoptosis as well as tumor growth.
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Ma, Y.-S., Shi, B.-W., Lu, H.-M., Xie, P.-F., Xin, R., Wu, Z.-J., Shi, Y., Yin, Y.-Z., Hou, L.-K., Jia, C.-Y., Wu, W., Lv, Z.-W., Yu, F., Wang, G.-R., Liu, J.-B., Jiang, G.-X., & Fu, D. (2021). MicroRNA-499 Serves as a Sensitizer for Lung Cancer Cells to Radiotherapy by Inhibition of CK2α-Mediated Phosphorylation of p65. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2021.03.016 Cite
Using mouse and cell culture models, the authors evaluated the effects of incense smoke exposure on airway hyperresponsiveness, expression of multiple epithelial tight junction- and adherens junction-associated mRNAs and proteins in the lungs, and the barrier function of bronchial epithelial cells assessed by transepithelial electronic resistance.
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Yamamoto, N., Kan-o, K., Tatsuta, M., Ishii, Y., Ogawa, T., Shinozaki, S., Fukuyama, S., Nakanishi, Y., & Matsumoto, K. (2021). Incense smoke-induced oxidative stress disrupts tight junctions and bronchial epithelial barrier integrity and induces airway hyperresponsiveness in mouse lungs. Scientific Reports, 11(1), 7222. https://doi.org/10.1038/s41598-021-86745-7 Cite
Investigators identified non-steroidal anti-inflammatory drugs (NSAIDs) that enhanced the anticancer effect of cisplatin; the effects of 17 NSAIDs in lung cancer cells and their spheroids as CSCs were evaluated.
[Toxicology in Vitro]
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Human umbilical cord (HUC)-MSCs were separated from the umbilical cord using the adherence method. Surface markers of HUC-MSCs were detected by flow cytometry for MSC identification.
[Cancer Biotherapy and Radiopharmaceuticals]
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Since different temperatures encountered in the human upper and lower respiratory tract have been shown to affect the replication kinetics of several respiratory viruses, as well as host immune response dynamics, scientists investigated the impact of temperatures during SARS-CoV-2 and SARS-CoV infection using the primary human airway epithelial cell culture model.
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V’kovski, P., Gultom, M., Kelly, J. N., Steiner, S., Russeil, J., Mangeat, B., Cora, E., Pezoldt, J., Holwerda, M., Kratzel, A., Laloli, L., Wider, M., Portmann, J., Tran, T., Ebert, N., Stalder, H., Hartmann, R., Gardeux, V., Alpern, D., … Dijkman, R. (2021). Disparate temperature-dependent virus–host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium. PLOS Biology, 19(3), e3001158. https://doi.org/10.1371/journal.pbio.3001158 Cite
miR-196a-overexpressed lung fibroblasts (LF-196a) promoted the migration and invasion of lung cancer cells in co-culture systems. ANXA1 was confirmed as a direct target of miR-196a, and adding back ANXA1 to LF-196a restored the cancer cell invasion promoted by miR-196a.
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Lee, S., Hong, J. H., Kim, J. S., Yoon, J. S., Chun, S. H., Hong, S. A., Kim, E. J., Kang, K., Lee Kang, J., Ko, Y. H., & Ahn, Y.-H. (2021). Cancer-associated fibroblasts activated by miR-196a promote the migration and invasion of lung cancer cells. Cancer Letters. https://doi.org/10.1016/j.canlet.2021.03.021 Cite
By integrating viral sequencing data from patient material, virus stocks, and passaging experiments, together with kinetic virus replication data from nonhuman Vero-CCL81 cells and primary differentiated human bronchial epithelial cells (BEpCs), scientists observed several SARS-CoV-2 features that associated with distinct phenotypes.
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Pohl, M. O., Busnadiego, I., Kufner, V., Glas, I., Karakus, U., Schmutz, S., Zaheri, M., Abela, I., Trkola, A., Huber, M., Stertz, S., & Hale, B. G. (2021). SARS-CoV-2 variants reveal features critical for replication in primary human cells. PLOS Biology, 19(3), e3001006. https://doi.org/10.1371/journal.pbio.3001006 Cite
Researchers demonstrated that tissue‑specific transplantation antigen P35B (TSTA3) was regulated by miR‑125a‑5p and functions as an oncogene in lung cancer via promoting the activation of β‑catenin signaling.
Scientists revealed that apigenin directed alternative splicing and inhibited Hsp70 enhancing tumor necrosis factor-related apoptosis-inducing ligand anticancer activity.
[Cell Death & Disease]
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Scientists applied a synthetic mRNA-driven strategy to generate neuronal precursors from hiPSCs. These neuronal precursors were transformed by the MYC oncogene combined with p53 loss-of-function to establish a MYC-driven medulloblastoma model recapitulating the histological and transcriptomic hallmarks of Group 3 MB.
[Molecular Cancer Therapeutics]
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Frondoside A Inhibits a MYC-driven Medulloblastoma Model Derived from Human Induced Pluripotent Stem Cells. | Molecular Cancer Therapeutics. (n.d.). Retrieved March 17, 2021, from https://mct.aacrjournals.org/content/early/2021/03/15/1535-7163.MCT-20-0603.long Cite