Plasma-Activated Medium as Adjuvant Therapy for Lung Cancer with Malignant Pleural Effusion

Researchers compared effects of plasma-activated medium with effects of conventional clinical thermal therapy on both lung cancer cells and benign cells for management of malignant pleural effusion.
[Scientific Reports]
Cheng, Y.-J., Lin, C.-K., Chen, C.-Y., Chien, P.-C., Chuan, H.-H., Ho, C.-C., & Cheng, Y.-C. (2020). Plasma-activated medium as adjuvant therapy for lung cancer with malignant pleural effusion. Scientific Reports, 10(1), 18154. https://doi.org/10.1038/s41598-020-75214-2 Cite
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Importin 13 Promotes NSCLC Progression by Mediating RFPL3 Nuclear Translocation and hTERT Expression Upregulation

The authors identified RFPL3 as a potential import cargo for IPO13, which was found to be overexpressed in NSCLC cells and tissues.
[Cell Death & Disease]
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ERK3/MAPK6 Is Required for KRAS-Mediated NSCLC Tumorigenesis

Investigators uncovered that ERK3, a ubiquitously expressed atypical MAPK, was required for KRAS-mediated NSCLC tumors. ERK3 is highly expressed in lung cancers, and oncogenic KRAS led to the activation and stabilization of the ERK3 protein.
[Cancer Gene Therapy]
Bogucka, K., Marini, F., Rosigkeit, S., Schloeder, J., Jonuleit, H., David, K., Schlackow, M., & Rajalingam, K. (2020). ERK3/MAPK6 is required for KRAS-mediated NSCLC tumorigenesis. Cancer Gene Therapy, 1–16. https://doi.org/10.1038/s41417-020-00245-w Cite
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Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Lung Injury in Rat Model of Bronchopulmonary Dysplasia by Affecting Cell Survival and Angiogenesis

Researchers found that human umbilical cord MSCs-derived small extracellular vesicles were successfully absorbed by lung tissue after intratracheal administration, and remained in the lungs for at least 72 hours.
[Stem Cells and Development]
You, J., Zhou, O., Liu, J., Zou, W., Zhang, L., Tian, D., Dai, J., Luo, Z., Liu, E., Fu, Z., & Zou, L. (2020). Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Lung Injury in Rat Model of Bronchopulmonary Dysplasia by Affecting Cell Survival and Angiogenesis. Stem Cells and Development. https://doi.org/10.1089/scd.2020.0156 Cite
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In Primary Airway Epithelial Cells, the Unjamming Transition Is Distinct from the Epithelial-to-Mesenchymal Transition

Scientists triggered partial epithelial-to-mesenchymal transition or unjamming transition in differentiated primary human bronchial epithelial cells.
[Nature Communications]
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Transcriptional Subtypes Resolve Tumor Heterogeneity and Identify Vulnerabilities to MEK Inhibition in Lung Adenocarcinoma

75% of adenocarcinomas lack targeted therapies due to scarcity of druggable drivers. The authors classified tumors based on signaling similarities and discovered subgroups within this unmet patient population.
[Clinical Cancer Research]
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Fatty Acid-Binding Protein 5 Limits ILC2-Mediated Allergic Lung Inflammation in a Murine Asthma Model

The authors examined the role of fatty acid-binding protein 5 (FABP5) in the allergic lung inflammation and demonstrated that the expression of FABP5 acts as a novel positive regulator of ST2 expression in alveolar epithelial cells (ECs) to generate retinoic acid (RA) and supports the synthesis of RA from type II alveolar ECs to suppress excessive activation of innate lymphoid cell 2 during allergic lung inflammation.
[Scientific Reports]
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Aspirin Overcomes Cisplatin Resistance in Lung Cancer by Inhibiting Cancer Cell Stemness

Scientists used aspirin, a nonselective COX inhibitor, with cisplatin for several hours in cells and days in vivo, and studied the inhibition against human cisplatin‐resistant H460 cells.
[Thoracic Cancer]
Zhao, M., Wang, T., & Hui, Z. (n.d.). Aspirin overcomes cisplatin resistance in lung cancer by inhibiting cancer cell stemness. Thoracic Cancer, n/a(n/a). https://doi.org/10.1111/1759-7714.13619 Cite
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Spred2-Deficiency Enhances the Proliferation of Lung Epithelial Cells and Alleviates Pulmonary Fibrosis Induced by Bleomycin

Scientists examined the role of Sprouty-related EVH-1-domain-containing protein (Spred) 2, a negative regulator of the MAPK-ERK pathway, in the development of bleomycin-induced pulmonary fibrosis.
[Scientific Reports]
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Small GTPase RAB6 Deficiency Promotes Alveolar Progenitor Cell Renewal and Attenuates PM2.5-Induced Lung Injury and Fibrosis

Investigators demonstrated that knockout of RAB6 inhibited pulmonary fibrosis, oxidative stress, and type 2 alveolar epithelial cells (AEC2) cell death in fine particulate matter (PM2.5)-injured mice. In addition, knockout of RAB6 decreased Dickkopf 1 autocrine and activated proliferation, self-renewal, and wnt/β-catenin signaling of PM2.5-injured AEC2 cells.
[Cell Death & Disease]
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Mutual Regulation between OGT and XIAP to Control Colon Cancer Cell Growth and Invasion

Researchers identified X-linked inhibitor of apoptosis (XIAP) as the main E3 ubiquitin ligase in colon cancer cells. O-GlcNAc transferase (OGT) catalyzed the O-GlcNAc modification of XIAP at serine 406 and this modification was required for the E3 ubiquitin ligase activity of XIAP toward specifically OGT. O-GlcNAcylation of XIAP suppressed colon cancer cell growth and invasion by promoting the proteasomal degradation of OGT.
[Cell Death & Disease]
Seo, H. G., Kim, H. B., Yoon, J. Y., Kweon, T. H., Park, Y. S., Kang, J., Jung, J., Son, S., Yi, E. C., Lee, T. H., Yang, W. H., & Cho, J. W. (2020). Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-02999-5 Cite
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