Pretreatment of Aged Mice with Retinoic Acid Supports Alveolar Regeneration via Upregulation of Reciprocal PDGFA Signaling

In vitro organoids generated from epithelial cells of mouse or patient with idiopathic pulmonary fibrosis co-cultured with young, aged or retinoic acid-pretreated murine fibroblasts were used to test potential targets.
[Thorax]
Gokey, J. J., Snowball, J., Green, J., Waltamath, M., Spinney, J. J., Black, K. E., Hariri, L. P., Xu, Y., & Perl, A. K. (2021). Pretreatment of aged mice with retinoic acid supports alveolar regeneration via upregulation of reciprocal PDGFA signalling. Thorax. https://doi.org/10.1136/thoraxjnl-2020-214986 Cite
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Secretoglobin 3A2 Eliminates Human Cancer Cells through Pyroptosis

Researchers showed that secretoglobin 3A2 exhibits marked anti-cancer activity against 5 out of 11 of human non-small cell lung cancer cell lines in mouse xenographs, while no effect was observed in 6 of 6 small cell lung cancer cell lines examined.
[Cell Death Discovery]
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Extracellular Vesicles‐Encapsulated let‐7i Shed from Bone Mesenchymal Stem Cells Suppress Lung Cancer via KDM3A/DCLK1/FXYD3 Axis

Scientists investigated the modulatory role of bone marrow mesenchymal stem cell‐EV‐derived let‐7i and their molecular mechanism in lung cancer progression.
[Journal of Cellular and Molecular Medicine]
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Intermittent Hypoxia-Induced Downregulation of MicroRNA-320b Promotes the Lung Cancer Tumorigenesis by Increasing CDT1 via USP37

Scientists explored the functional roles of microRNAs in lung cancer patients that were complicated with obstructive sleep apnea-hypopnea involving the deubiquitination enzyme. The miR-320b expression pattern in lung cancer tissues and cells was determined.
[Molecular Therapy-Nucleic Acids]
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Dual Inhibition of MEK and AXL Targets Tumor Cell Heterogeneity and Prevents Resistant Outgrowth Mediated by the Epithelial-to-Mesenchymal Transition in NSCLC

Researchers integrated the data from a selective drug screen in epithelial and mesenchymal Kras/p53 mutant lung tumor cells with separate datasets including reverse phase protein array and an in vivo shRNA dropout screen.
[Cancer Research]
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Alveolar Epithelial Cell‐Derived Sonic Hedgehog Promotes Pulmonary Fibrosis through OPN‐Dependent Alternative Macrophage Activation

Scientists investigated the interaction between macrophages and fibrosis‐associated alveolar epithelial cells using a bleomycin‐induced mouse pulmonary fibrosis model and a co‐culture system.
[FEBS Journal]
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Outer Membrane Vesicles Derived from Klebsiella pneumoniae Influence the miRNA Expression Profile in Human Bronchial Epithelial BEAS-2B Cells

miRNA expression profiles in human bronchial epithelial cells were evaluated during infection with standard and clinical K. pneumoniae strains.
[Microorganisms]
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Albanol B from Mulberries Exerts Anti-Cancer Effect through Mitochondria ROS Production in Lung Cancer Cells and Suppresses In Vivo Tumor Growth

Scientists showed that albanol B inhibited the proliferation of four human lung cancer cell lines and induced apoptosis, based on the cleavage of caspase-7 and PARP, as well as the downregulation of Bcl-2.
[International Journal of Molecular Sciences]
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Sequential Ubiquitination of p53 by TRIM28, RLIM, and MDM2 in Lung Tumorigenesis

The stable overexpression of tripartite motif-containing 28 (TRIM28) in lung cancer cells and xenograft models significantly increased the proliferation, migration, and invasiveness, whereas knockdown of TRIM28 had the opposite effect.
[Cell Death & Differentiation]
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K2P2.1 (TREK-1) Potassium Channel Activation Protects against Hyperoxia-Induced Lung Injury

Investigators treated hyperoxia-exposed mice and primary alveolar epithelial cells with the novel TREK-1 activators ML335 and BL1249, and quantified physiological, histological, and biochemical lung injury markers.
[Scientific Reports]
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Geomagnetic Shielding Enhances Radiation Resistance by Promoting DNA Repair Process in Human Bronchial Epithelial Cells

Immortalized human bronchial epithelial cells were exposed to X-rays under either a geomagnetic field or hypomagnetic field (HMF) culture condition. A significant increase of the cell survival rate in HMF after radiation was observed by colony formation analysis.
[International Journal of Molecular Sciences]
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