acute myeloid leukemia

[Nature Communications] Researchers showed that pyruvate dehydrogenase kinase 1 (PDK1) acted as a targetable determinant of different metabolic states in AML.

[Bone Marrow Transplantation] Scientists investigated whether gilteritinib, a selective FLT3 inhibitor, could enhance graft-versus-leukemia effects against FLT3 internal tandem duplication mutant transfected Ba/F3 leukemia in mice.

[Clinical and Translational Oncology] The authors highlight various studies on autophagic pathways and describe the role of autophagy in cancer, specifically AML.

[Scientific Reports] Investigators discovered a mechanical correlation between leucine proline-enriched proteoglycan 1 (LEPRE1) and pelitinib drug sensitivity using in silico statistical methods and confirmed the correlation in acute myeloid leukemia and A549 lung cancer cells.

[El Paso Herald-Post] Texas Tech University Health Sciences Center (TTUHSC) El Paso has received more than a quarter-million dollars to study the proteins that contribute to disease progression and drug resistance in AML and chronic myeloid leukemia.

[Science Advances] Investigators revealed that CCRL2 was up-regulated in primitive cells from patients with myelodysplastic syndrome and secondary AML.