acute myeloid leukemia

[Nature Communications] To target GRP78, scientists generated T cell expressing a GRP78-specific peptide-based CAR, which showed evidence of minimal fratricide post activation/transduction and antigen-dependent T cell differentiation.

[Communications Biology] Researchers demonstrated that platelets with structurally abnormal mitochondria emerged at the pre-leukemic phase of acute myeloid leukemia, preceding detectable changes in blood cell counts or detection of leukemic blasts in blood.

[Scientific Reports] To find additional hematologic entities with ectopic expression of BCL2 family members, investigators performed expression screening of cell lines applying the LL-100 panel.

[Stem Cell Reviews and Reports] The authors review leukemia stem cell biology, particularly as it relates to the very heterogeneous nature of acute myeloid leukemia and to its high disease relapse rate.

[Cancer Discovery] The authors leveraged genetic mouse models, patient-derived xenografts, and patient samples to show that acute myeloid leukemia exploited peripheral serotonin-signaling to remodel the endosteal niche to its advantage.

[Cancer Immunology Immunotherapy] Scientists investigated in vitro, ex vivo and in vivo effects of a novel chemical compound targeting HCK inhibition, in combination with the most used drugs for the treatment of myelodysplastic syndrome and de novo acute myeloid leukemia, 5-Azacytidine and Cytarabine.