acute myeloid leukemia

[Molecular Biology Reports] Scientists review studies characterizing the role of ALDH1A1 in acute myeloid leukemia and its potential as a therapeutic target.

[Nature Medicine] The authors edited the TRAC locus in human peripheral blood T cells to engage cell-surface targets through their T cell receptor–CD3 complex reconfigured to utilize the same immunoglobulin heavy and light chains as a matched CAR.

[Century Therapeutics] Century Therapeutics and Bristol Myers Squibb announced a research collaboration and license agreement to develop and commercialize up to four iPSC derived, engineered natural killer cell and / or T cell programs for hematologic malignancies and solid tumors.

[Cell Reports] Investigators showed that STK35 and PDIK1L function catalytically and redundantly in the same pathway as SCP4 to maintain acute myeloid leukemia proliferation and to support amino acid biosynthesis and transport.

[Journal of Nanobiotechnology] Researchers investigated the effects of exosomes derived from bone marrow mesenchymal stem cells on the regulation of acute myeloid leukemia and the underlying mechanisms mediated by microRNA.

[Frontiers in Oncology] The authors report on mechanism of action, safety, and efficacy data on combination strategies based on hypomethylating agents in the setting of post-allogeneic stem cell transplant relapse.