adipocytes

[Nature Metabolism] FA2H was a direct target of miR-3075 and small interfering RNA depletion of FA2H in adipocytes, myocytes and primary hepatocytes led to increased insulin sensitivity. In chronic obesity, hepatocyte exosomes promoted a state of insulin resistance.

[FASEB Journal] Researchers described a method that allowed the use of frozen human skeletal muscle biopsies to simultaneously isolate and grow catellite cells and fibroadipogenic progenitors cells from healthy or dystrophic patients.

[Scientific Reports] Investigators showed that intramuscular injection of placental (P)-MSCs homed more towards the visceral site, restored HOMA-IR and glucose homeostasis in the WNIN/GR-Ob rats. P-MSC therapy was effective in re-establishing the dysregulated cytokines.

[Tissue Engineering Part A] Scientists prepared cartilage from human iPSCs (hiPS-Cart) in a scaffoldless manner and implanted hiPS-Cart into 3.5 mm large defects created in the femurs of immunodeficient mice to examine the repair capacity.

[Journal of Cellular and Molecular Medicine] Researchers compared the therapeutic potential of induced pluripotent stem cells differentiation into MSCs generated from urinary epithelial cells with the available umbilical cord MSCs.

[Scientific Reports] Researchers hypothesized that increased intracellular S-adenosylhomocysteine alone caused additional related pathological changes in adipose tissue as seen with alcohol administration.