AIDS

Montefiore Health System and Albert Einstein College of Medicine have received a five-year, $111 million grant from the National Cancer Institute to lead this research consortium.

[Cell Communication and Signaling] Researchers showed that the non-nucleoside reverse transcriptase inhibitors, SPV122 in combination with MEK inhibitors strongly inhibited BRAF-mutant melanoma cell growth, induced apoptosis, and delayed the emergence of resistance to target therapy in vitro.

[Journal of Clinical Investigation] Scientists demonstratd that sphingosine kinase 2 functioned during lymphocytic choriomeningitis virus Cl 13 infection to limit T cell immune pathology, which subsequently aided in the establishment of virus-induced immunosuppression and the resultant viral persistence.

[Scientific Reports] Researchers investigated whether REV-ERB activity regulates HIV-1 replication and found REV-ERB agonists inhibited HIV-1 promoter activity in cell lines, primary human CD4 T cells and macrophages, whilst antagonism or genetic disruption of REV-ERB increased promoter activity.

[ScienceInsider] As large trials get underway to test the vaccines needed to stop the global coronavirus pandemic, one group has realized it is being left out and is not happy: people living with HIV.

[Scientific Reports] Scientists investigated the in vivo regulation of IFN-γ production by CD8+ T cells, DN T cells and NK cells in response to acute Toxoplasma gondii infection.