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airway epithelial cells

Toxicity of Stainless and Mild Steel Particles Generated from Gas–Metal Arc Welding in Primary Human Small Airway Epithelial Cells

[Scientific Reports] Scientists evaluated the toxicity of stainless and mild steel particles generated via gas–metal arc welding using primary human small airway epithelial cells and ToxTracker reporter murine stem cells, which tracked activation of six cancer-related pathways.

Serum-Derived Exosomes from House Dust Mite-Sensitized Guinea Pigs Contribute to Inflammation in BEAS-2B Cells via the TLR4-NF-κB Pathway

[Molecular Medicine Reports] The authors investigated whether serum exosomes played a pro‑inflammatory role in bronchial epithelial cells and explored the underlying molecular mechanisms.

Electronic Cigarette Smoke Reduces Ribosomal Protein Gene Expression to Impair Protein Synthesis in Primary Human Airway Epithelial Cells

[Scientific Reports] Researchers reported transcriptomic changes, including decreased expression of many ribosomal genes, in airway epithelial cells in response to e-cig exposure.

Cells of the Human Respiratory Tract Support the Replication of Pathogenic Old World Orthohantavirus Puumala

[Virology Journal] Researchers analyzed the permissiveness of primary endothelial cells of the human pulmonary microvasculature and of primary human epithelial cells derived from bronchi, bronchioles and alveoli for Old World orthohantavirus Puumala virus in vitro.

YAP Regulates Alveolar Epithelial Cell Differentiation and AGER via NFIB/KLF5/NKX2-1

[iScience] Postnatal YAP activation increased epithelial cell proliferation, increased alveolar type-1 cell numbers, and caused indeterminate differentiation of subsets of alveolar cells expressing atypical genes normally restricted to airway epithelial cells.

Disease Modeling Following Organoid-Based Expansion of Airway Epithelial Cells

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Airway epithelial cells were obtained from tracheal aspirates (TA) from preterm newborns, and from bronchoalveolar lavage (BAL) or bronchial tissue (BT) from adults. TA and BAL cells were 3D-expanded, whereas cells from BT were expanded in 3D and 2D.

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