airway epithelial cells

[Cell Death & Disease] Scientists demonstrated that fibroblast growth factor-binding protein 1 was dramatically upregulated in airway epithelial cell lines treated by poly-L-arginine, a mimic of major basic protein.

[Scientific Reports] Primary human airway epithelial cells, cultured at air–liquid interface, were obtained by clinical airway brushings or from explanted lungs. Human airway Hb mRNA data were from publically available databases; or from RT-PCR.

[Nature Communications] Scientists demonstrated that healthy and idiopathic pulmonary fibrosis (IPF) airway epithelia were biophysically distinct, identifying pathologic activation of the ERBB-YAP axis as a specific and modifiable driver of prolongation of the unjammed-to-jammed transition in IPF epithelia.

[Biomaterials] The authors established an expansion system of hPSC-derived lung progenitors based on their 3D culture in core-shell hydrogel microfibers, that ensures the maintenance of their bipotency for differentiation into alveolar and airway epithelial cells including alveolar type II cells.

[Scientific Reports] Scientists integrated human primary airway epithelial cells into a custom-engineered 96-device platform in which tissues were cultured in an array of microchannel-based culture chambers at an air–liquid interface, in a configuration compatible with high resolution in-situ imaging and real-time sensing.

[Experimental & Molecular Medicine] Researchers investigated the mechanism by which S100A9 was involved in neutrophil activation, neutrophil extracellular trap-induced airway inflammation, and macrophage polarization in neutrophilic asthma.