allograft models

[Nature Metabolism] Using cultured mesenchymal and cancer cells, as well as mouse allograft models, the authors provide evidence that extracellular lactate could be utilized by fibroblasts to maintain tricarboxylic acid cycle anaplerosis and non-essential amino acid biosynthesis through pyruvate carboxylase activity.

[Cancer Research] Researchers identified a regulator of Wnt/ß-catenin signaling, PLEKHA4, as a factor required for melanoma proliferation and survival.

[Circulation Research] Investigators report the transcriptional profiling of 11,868 cells in a mouse model of transplant arteriosclerosis by single-cell RNA sequencing.