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amyotrophic lateral sclerosis

Umbilical & Placental Cell News

Large-Scale Analysis of MicroRNA Expression in Motor Neuron-Like Cells Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells

[Scientific Reports] Human CB-MSCs were isolated and characterized using flow cytometry. Cell differentiation has been induced by combining retinoic acid and sonic hedgehog in a two-step protocol for 14 days.
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Neural Cell News

Retroviral Elements in Pathophysiology and as Therapeutic Targets for Amyotrophic Lateral Sclerosis

[Neurotherapeutics] Individuals with HIV-associated amyotrophic lateral sclerosis (ALS) show a remarkable response to antiretroviral therapy; however, antiretroviral trials in ALS down-regulate HML-2 without ameliorating the disease.
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Mesenchymal Cell News

Large-Scale Analysis of MicroRNA Expression in Motor Neuron-Like Cells Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells

[Scientific Reports] Scientists explored miRNA profiles of CB-MSCs during differentiation into motor neuron-like cells.
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Muscle Cell News

Cell Environment Shapes TDP-43 Function with Implications in Neuronal and Muscle Disease

[Communications Biology] Using RNA-seq, investigators directly compared TAR DNA-binding protein 43 (TDP-43)-mediated RNA processing in muscle C2C12 and neuronal NSC34 mouse cells.
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Neural Cell News

Excessive Release of Inorganic Phosphate by ALS/FTD Astrocytes Causes Non-Cell-Autonomous Toxicity to Motoneurons

[Neuron] Researchers reported that mouse and patient induced pluripotent stem cells-derived astrocytes with diverse ALS/frontotemporal dementia (FTD)-linked mutations (SOD1, TARDBP, and C9ORF72) displayed elevated levels of intracellular inorganic polyphosphate.
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Neural Cell News

Tissue-Engineered In Vitro Modeling of the Impact of Schwann Cells in Amyotrophic Lateral Sclerosis

[Biotechnology and Bioengineering] Scientists investigated whether Schwann cells could be involved in the disease pathogenesis, and developed a tissue-engineered 3D in vitro model that combined motor neurons cocultured with astrocytes.
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