amyotrophic lateral sclerosis

[Scientific Reports] Human CB-MSCs were isolated and characterized using flow cytometry. Cell differentiation has been induced by combining retinoic acid and sonic hedgehog in a two-step protocol for 14 days.

[Neurotherapeutics] Individuals with HIV-associated amyotrophic lateral sclerosis (ALS) show a remarkable response to antiretroviral therapy; however, antiretroviral trials in ALS down-regulate HML-2 without ameliorating the disease.

[Scientific Reports] Scientists explored miRNA profiles of CB-MSCs during differentiation into motor neuron-like cells.

[Communications Biology] Using RNA-seq, investigators directly compared TAR DNA-binding protein 43 (TDP-43)-mediated RNA processing in muscle C2C12 and neuronal NSC34 mouse cells.

[Biotechnology and Bioengineering] Scientists investigated whether Schwann cells could be involved in the disease pathogenesis, and developed a tissue-engineered 3D in vitro model that combined motor neurons cocultured with astrocytes.

[Neuron] Researchers reported that mouse and patient induced pluripotent stem cells-derived astrocytes with diverse ALS/frontotemporal dementia (FTD)-linked mutations (SOD1, TARDBP, and C9ORF72) displayed elevated levels of intracellular inorganic polyphosphate.