astrocytes

[Neuron] An inhibitory extracellular milieu and neuron-intrinsic processes prevent axons from regenerating in the adult central nervous system. Here scientists show how the two aspects are interwoven.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists reported that levels of nicotinamide adenine dinucleotide (NAD)+ were reduced and markers of inflammation increased in the brains of APP/PS1 mutant transgenic mice with beta-amyloid pathology.

[Light-Science & Applications] Researchers demonstrated that cognitive and memory impairment in an Alzheimer’s disease (AD) mouse model can be ameliorated by 1070-nm light via reducing cerebral β-amyloid (Aβ) burden, the hallmark of AD. The glial cells, including microglia and astrocytes, played important roles in Aβ clearance.

[Aging Cell] Scientists showed that the cGAS-STING pathway was required for the recognition of micronuclei and induction of a senescence-associated secretory phenotype in ataxia-telangiectasia olfactory neurosphere-derived cells and brain organoids.

[Nature Communications] Investigators generated a induced pluripotent stem cell Alzheimer's disease model using human derived cells, which showed signs of Aβ plaques, dystrophic neurites around plaques, synapse loss, dendrite retraction, axon fragmentation, phospho-Tau induction, and neuronal cell death in one model.

[Scientific Reports] Researchers showed here that astrocyte elevated gene-1 (AEG-1) was overexpressed in glioma tissues and associated with a worse subtype and a poor prognosis.