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Pulmonary Cell NewsScientists showed that the cGAS-STING pathway was required for the recognition of micronuclei and induction of a senescence-associated secretory phenotype in ataxia-telangiectasia olfactory neurosphere-derived cells and brain organoids.
[Aging Cell]
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Aguado, J., Chaggar, H. K., Gómez-Inclán, C., Shaker, M. R., Leeson, H. C., Mackay-Sim, A., & Wolvetang, E. J. (n.d.). Inhibition of the cGAS-STING pathway ameliorates the premature senescence hallmarks of Ataxia-Telangiectasia brain organoids. Aging Cell, n/a(n/a), e13468. https://doi.org/10.1111/acel.13468 Cite
