breast cancer stem cells

[Stem Cells] The authors discuss the role of epithelial‐mesenchymal transition of breast cancer stem cells (BCSCs) in the setting of trastuzumab resistance and approaches of reducing or eradicating BCSCs in HER2‐positive breast cancer.

[Biochimica Et Biophysica Acta-Molecular Basis of Disease] Scientists report that TWIST1, an epithelial-to-mesenchymal transition (EMT) regulated by transcription factors, exhibited positive transcriptional regulation on PDGFRβ promoter, thus identifying PDGFRβ as one of the downstream targets of EMT regulation in breast CSCs.

[Life Sciences] The authors demonstrated that the miRNA miR-142-3p directly targeted the 3′ untranslated region of HMGA2, which encoded an onco-embryonic protein that was overexpressed in most cancers, including breast cancer.

[Seminars in Cancer Biology] Investigators summarized the novel regulators existed in breast cancer stem cells (BCSCs) and their niches for BCSC heterogeneity which has been discovered in recent years, and discuss their regulation mechanisms and the latest corresponding cancer treatments.

[Oncogene] Researchers demonstrated greater expression of TMCC3 in breast cancer stem cells (BCSCs) than non-BCSCs and higher expression of TMCC3 in metastatic lymph nodes and lungs than in primary tumor of breast cancer patient-derived xenograft.

[Biomedical Materials] The authors developed a 3D culture platform that mimics the metastatic tumor extracellular matrix to effectively increase cancer stem cell (CSC) population in vitro and allow CSC analysis.