breast cancer

[Cell Death & Disease] Knockout of diacylglycerol kinase ζ (DGKZ) in TNBC cell lines were found to significantly inhibit metastatic behaviors in vitro and in vivo, whereas its overexpression increased the metastatic potential of cell lines.

[Future Oncology] The authors discuss potential resistance mechanisms to CDK4/6 inhibitors, the use of biomarkers to guide treatment for hormone receptor-positive, HER2- negative metastatic breast cancer and possible approaches to overcome resistance to CDK4/6 inhibitors.

[Current Oncology Reports] Scientists describe innovative treatment strategies on the horizon for breast cancer and central nervous metastases.

[Biochemical and Biophysical Research Communications] Scientists observed an increased level of EMT markers in CSC population. Overexpression of secretory phospholipase sPLA2-IIA was found in CSCs.

[Advanced Healthcare Materials] Researchers used a recently developed composite hydrogel composed of a fibrin matrix and phase-shift emulsion, termed an acoustically-responsive scaffold, to investigate effects of local mechanical properties on breast cancer cell signaling.

[Oncogene] Scientists revealed that Hippo signaling effector YAP1 functioned as a key downstream regulator of LIN28 to modulate the CSC-like properties and tumor progressions in triple negative breast cancer.