DGKZ Promotes TGFβ Signaling Pathway and Metastasis in Triple-Negative Breast Cancer by Suppressing Lipid Raft-Dependent Endocytosis of TGFβR2

Knockout of diacylglycerol kinase ζ (DGKZ) in TNBC cell lines were found to significantly inhibit metastatic behaviors in vitro and in vivo, whereas its overexpression increased the metastatic potential of cell lines.