breast cancer

[Scientific Reports] The authors characterized the anticancer activity of the A. testudineus antimicrobial peptides, which were synthetically produced and subjected to cytotoxic assay to prove their efficacy against cancer cell lines.

[Bioengineered] Researchers found high TSPAN1 expression in breast cancer tumor samples and cell lines which was confirmed by bioinformation analysis. The ablation of TSPAN1 suppressed the growth, and motility of breast cancer cells and affected the epithelial-mesenchymal transition in breast cancer cells.

[npj Breast Cancer] The authors discuss the biological understanding of tumor-infiltrating lymphocytes (TILs), their analytical and clinical validity and efforts towards the clinical utility in breast cancer, and the current status of programmed death-ligand 1and TIL testing across different continents.

[Breast Cancer Research and Treatment] Breast cancer is immunogenic and a variety of vaccines have been designed to boost immunity directed against the disease. Newer approaches are designing vaccines to prevent breast cancer by intercepting high-risk lesions such as ductal carcinoma in situ to limit the progression of these tumors to invasive cancer.

[Small] It was observed that poly(2-oxazoline)-based polymeric micelles could be elongated over time from a spherical structure to worm-like structure, with elongation influenced by several conditions, including the amount and type of drug loaded into the micelles.

[Journal of Cellular Biochemistry] Scientists used two colon cancer cell lines, HT29 and HCT116 cells, to investigate whether fraxetin could inhibit the capabilities acquired during tumor development. In this study, fraxetin suppressed cell viability and induced apoptotic cell death in HT29 and HCT116 cells.