breast cancer

[Cell Death & Disease] Scientists explored the role of MTDH in regulating the sensitivity of breast cancer cell lines to gemcitabine and the potential miRNAs targeting MTDH.

[Cellular Signalling] Researchers performed in silico analysis of microarray data from luminal, Her2+, and triple-negative breast cancer cell lines and identified 15 relatively unexplored epithelial-to-mesenchymal (EMT)-related differentially expressed genes along with the markedly high expression of EMT-transcription factor, SNAI1.

[Scientific Reports] Investigators identified the oncogenic features of TNFSF4 in breast carcinoma. TNFSF4 was revealed to be closely related to treatment that induced antitumor immunity and to interact with multiple immune effector molecules and T cell signatures

[Cell] Scientists showed that nuclear envelope ruptures induced DNA damage that promoted senescence in non-transformed cells and induced an invasive phenotype in human breast cancer cells.

[Nano Letters] Mechanism studies revealed that after linking these immunogenic cell death inert monomers into the covalent organic frameworks (COFs) backbone, the optical properties of these COFs could be systematically tuned to achieve excellent reactive oxygen species production performance.

[EMBO Journal] Investigators showed that the novel oncogene RASSF1C drove mesenchymal-to-amoeboid transition and stem cell attributes in breast cancer cells. Mechanistically, RASSF1C activated Rho/ROCK via SRC-mediated RhoGDI inhibition, resulting in generation of actomyosin contractility.