breast cancer

[Journal of Antibiotics] Arthrifuranone A was isolation from an EtOAc-extract of Arthrinium pseudosinense culture medium and evaluated for its estrogenic activity using the MCF-7 estrogen responsive human breast cancer cells.

[British Journal of Cancer] Ubiquitin carboxyl terminal hydrolase L1 (UCHL1), a ubiquitin C-terminal hydrolase belonging to the deubiquitinase family of enzymes, is highly expressed in metastatic estrogen receptor negative breast cancer and TNBC, and several key reports have revealed emerging and important roles for UCHL1 in breast cancer.

[Memorial Sloan Kettering Cancer Center] Memorial Sloan Kettering Cancer Center has received a major grant from the US National Institutes of Health to conduct research related to leukemia.

[Nature Communications] The authors described identification of 1089 gene-centric common insertion sites (gCIS) from transposon-based screens in 8 mouse models of breast cancer (BC). Most gCIS showed single allele disruption and many mapped to genomic regions showing high-frequency hemizygous loss in human BC.

[Nature Genetics] Investigators presented a single-cell and spatially resolved transcriptomics analysis of human breast cancers. They developed a single-cell method of intrinsic subtype classification to reveal recurrent neoplastic cell heterogeneity.

[Journal of Bone and Mineral Research] In estrogen receptor positive (ER+) cells, oncostatin M (OSM) robustly stimulated phosphorylation of known gp130 signaling targets STAT3, ERK and AKT, while CNTF activated STAT3 signaling. In ER- breast cancer cells, OSM alone stimulated AKT and ERK signaling.