bronchial epithelial cells

[Molecular Cancer Research] A transgenic mouse model expressing human Caspase-9b in the lung pneumocytes developed inflammatory lung lesions, which correlated with enhanced activation of the NF-κB pathway and increased influx of immunosuppressive MDSCs in contrast to wild-type mice.

[Science Translational Medicine] In human bronchial epithelial cells, phosphoinositide 3-kinase γ (PI3Kγ) mimetic peptide induced unexpected cyclic adenosine monophosphate and protein kinase A elevations restricted to the vicinity of the cystic fibrosis transmembrane conductance regulator (CFTR), the ion channel controlling mucus hydration that is mutated in CF.

[Toxicological Sciences] Researchers investigated the mechanism of hexavalent chromium carcinogenesis focusing on the role of the epitranscriptomic dysregulation.

[Genes and Environment] Researchers quantitatively measured the methylation content of Alu and LINE1 in particulate matter-treated normal human bronchial epithelial cells and normal human epidermal keratinocytes by using whole-genome bisulfite sequencing and pyrosequencing.

[Environmental Science and Pollution Research] The authors examined the viability of BEAS-2B and mRNA/protein expression profile of oxidative stress and inflammatory response-related transcription factors Nrf2, NF-kB, and according inflammatory indicators such as IL-1, IL-6, and IL-8, with a view to evaluating the effects of different interaction models of PM2.5 on epithelial cell damage in vitro.

[Scientific Reports] Investigators expanded and differentiated human basal cells isolated from the nasal and conducting airway to a mature mucociliary epithelial cell layer at air–liquid interface using a medium formulation containing normal resting glucose levels.