cancer stem cells

[FEBS Journal] Investigators observed that the increase of Sox9 significantly promoted hepatocellular carcinoma cell growth and invasion in cell cultures, whereas knockdown of Sox9 showed the opposite effects, suggesting that Sox9 may regulate the proliferation and invasion of hepatoma cells in an autocrine manner.

[Molecular Oncology] The authors identified that autophagy flux was inhibited in triple-negative breast cancer (TNBC) stem cells. miRNA-181a (miR-181a) expression is upregulated both in TNBC CSCs and patient tissues.

[Molecular Biotechnology] Stem cells from colorectal cancer HCT116 and CACO2 cells were isolated. TPT1-AS1 was significantly highly expressed in the CSCs compared to non-stem cells.

[Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences] Scientists summarize the current knowledge of the role of CD133 expression in gastic cancer and aim to contribute at identifying promising new strategies for treatment and management of gastric cancer.

[Molecular Biology Reports] Scientists review studies characterizing the role of ALDH1A1 in acute myeloid leukemia and its potential as a therapeutic target.

[Oncogene] Scientists discovered that PD-L1 interacted with receptor Frizzled 6 to activate β-catenin signaling and increase β-catenin-targeted gene expression, such as a putative stem cell marker leucine-rich-repeat-containing G-protein-coupled receptor 5.