PD-L1 Interacts with Frizzled 6 to Activate β-Catenin and Form a Positive Feedback Loop to Promote Cancer Stem Cell Expansion

Scientists discovered that PD-L1 interacted with receptor Frizzled 6 to activate β-catenin signaling and increase β-catenin-targeted gene expression, such as a putative stem cell marker leucine-rich-repeat-containing G-protein-coupled receptor 5.