cancer stem cells

[Molecular Cancer Research] The authors demonstrated that MUC1-C drove global changes in chromatin architecture in the dedifferentiation of CRPC and triple-negative breast cancer cells.

[Cell Death & Disease] Knockdown of MnSOD inhibited TNBC cell invasion, breast cancer stem cells, mitochondrial reactive oxygen species, and interleukin-6 excretion promoted by multiple copies in T cell malignancy-1.

[Oncogene] The authors investigated breast cancer cell metabolism reprogramming by circular RNAs (circRNAs) from breast cancer stem cell (BCSC) exosomes and found that BCSC exosome-derived circCARM1 played an important role in breast cancer cell glycolysis by sponging miR-1252-5p which regulated PFKFB2 expression.

[Biomedicine & Pharmacotherapy] Scientists discuss the latest developments in breast cancer stem cells (BCSCs) research, focusing on the analysis of specific markers, critical signaling pathways that maintain the stemness of BCSCs, such as NOTCH, Wnt/β-catenin, STAT3, Hedgehog, and Hippo-YAP signaling.

[Developmental Cell] A derived quiescent cancer-stem-cell-specific gene expression signature was enriched in pre-formed patient glioblastoma xenograft single-cell clusters that lacked proliferative gene expression.

[Bioengineered] Scientist found ZNF267 was significantly upregulated in diffuse large B-cell lymphoma and predicted a poor survival outcome based on the bioinformatics analysis.