cancer stem cells

[Cancer and Metastasis Reviews] Oncobiosis in breast cancer supports invasion, metastasis, and recurrence by supporting cellular movement, epithelial-to-mesenchymal transition, cancer stem cell function, and diapedesis. The microbiome provides novel leverage on breast cancer that should be exploited for better management of the disease.

[Biochemical and Biophysical Research Communications] A small molecule EHMT-2 inhibitor, BIX-01294, was evaluated for its activity in inhibiting cancer stem cells in human colorectal cancer by in vitro and in vivo experiments.

[Cancer Letters] Scientists discovered a specificity protein 1-induced long noncoding RNA—DPPA2 upstream binding RNA (DUBR) and its high expression in hepatocellular carcinoma tissues and liver CSCs.

[Medical Oncology] Scientists assessed adipogenic differentiation and its effect on the proliferation and stemness markers in CD44+ oral squamous cell carcinoma (OSCC) CSCs. D44+ CSCs were sorted by magnetic sorting from the single-cell suspension of the OSCC tumor.

[Oncogene] Scientists discovered an intrinsic signaling scaffold function of THEMIS2, which acted as a novel regulator of cancer stemness in promoting multiple cancer stemness properties including sphere formation, stemness markers expression, chemoresistance and tumorigenicity with low numbers of cancer cells implantation.

[International Journal of Oncology] The expression and effect of miR‑1291 in colorectal cancer cells (CRC) was investigated. It was identified that miR‑1291 significantly suppressed the proliferation, invasion, cell mobility and colony formation of CRC cells.