Novel Function of THEMIS2 in the Enhancement of Cancer Stemness and Chemoresistance by Releasing PTP1B from MET

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Scientists discovered an intrinsic signaling scaffold function of THEMIS2, which acted as a novel regulator of cancer stemness in promoting multiple cancer stemness properties including sphere formation, stemness markers expression, chemoresistance and tumorigenicity with low numbers of cancer cells implantation.
[Oncogene]

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Abstract