cancer stem cells

[Acta Neuropathologica Communications] Investigators profiled CSC-related long non-coding RNAs (lncRNAs) between radioresistant and parental medulloblastoma cells. The roles of the lncRNA RBM5-AS1 in the stemness and radiosensitivity of medulloblastoma cells were investigated.

[Cancer Immunology, Immunotherapy] To determine the immune-modulatory influence of CSC in small cell lung cancer (SCLC), scientists focused on the characterization of CD44+CD90+ CSC-like subpopulations in SCLC.

[Cancer Biology & Therapy] Scientists showed that fibroblast growth factor receptor 2 (FGFR2), particularly the IIIb isoform, was highly expressed in non-CSCs.

[Oncogene] Investigators demonstrated that ZEB2, the transcription factor of epithelial–mesenchymal transition, was upregulated in ascites cells from high-grade serous ovarian cancer patients and in CD133+ cancer stem-like cells from epithelial ovarian cancer cell lines.

[IUBMB Life] Investigators describe different therapeutic strategies such as immunotherapy, metabolism-based therapeutic strategies, and additional potential therapeutic approaches against CSCs.

[Journal of Experimental & Clinical Cancer Research] To improve clinical management of cancer, it is crucial to understand and learn how to manage the close interaction between tumor microenvironment and metastasis.